ID   MPG1_SULAC              Reviewed;         359 AA.
AC   P37820; Q4JC64;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Putative mannose-1-phosphate guanyltransferase;
DE            EC=2.7.7.13;
DE   AltName: Full=ATP-mannose-1-phosphate guanylyltransferase;
DE   AltName: Full=GDP-mannose pyrophosphorylase;
DE   AltName: Full=NDP-hexose pyrophosphorylase;
GN   Name=mpg1; OrderedLocusNames=Saci_0196;
OS   Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC
OS   15157 / NCIMB 11770).
OC   Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC   Sulfolobus.
OX   NCBI_TaxID=330779;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770;
RX   PubMed=15995215; DOI=10.1128/jb.187.14.4992-4999.2005;
RA   Chen L., Bruegger K., Skovgaard M., Redder P., She Q., Torarinsson E.,
RA   Greve B., Awayez M., Zibat A., Klenk H.-P., Garrett R.A.;
RT   "The genome of Sulfolobus acidocaldarius, a model organism of the
RT   Crenarchaeota.";
RL   J. Bacteriol. 187:4992-4999(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-142.
RX   PubMed=8334170; DOI=10.1016/0167-4781(93)90099-y;
RA   Klenk H.-P., Schleper C., Schwass V., Brudler R.;
RT   "Nucleotide sequence, transcription and phylogeny of the gene encoding the
RT   superoxide dismutase of Sulfolobus acidocaldarius.";
RL   Biochim. Biophys. Acta 1174:95-98(1993).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; CP000077; AAY79615.1; -; Genomic_DNA.
DR   EMBL; X63386; CAA44994.1; -; Genomic_DNA.
DR   PIR; S34617; S34617.
DR   RefSeq; WP_011277116.1; NC_007181.1.
DR   AlphaFoldDB; P37820; -.
DR   SMR; P37820; -.
DR   STRING; 330779.Saci_0196; -.
DR   EnsemblBacteria; AAY79615; AAY79615; Saci_0196.
DR   GeneID; 3474009; -.
DR   KEGG; sai:Saci_0196; -.
DR   PATRIC; fig|330779.12.peg.188; -.
DR   eggNOG; arCOG00666; Archaea.
DR   HOGENOM; CLU_029499_0_2_2; -.
DR   OMA; PFLTHQL; -.
DR   Proteomes; UP000001018; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   GTP-binding; Nucleotide-binding; Nucleotidyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..359
FT                   /note="Putative mannose-1-phosphate guanyltransferase"
FT                   /id="PRO_0000068742"
FT   CONFLICT        140
FT                   /note="Missing (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   359 AA;  39721 MW;  E61047D1787C1F23 CRC64;
     MVSAIVLAGG YATRLRPLSL TKPKALLPVL GKPLMDYTLY SLASSDVDTI YLSLRVMADK
     VLDHVKQLNL QKNIVSVIEE SRLGDAGPLK FINSKYNLSD DVIVVYGDIY AEIDFNKLLE
     YHQSKGCNAT LTATQVEDPS RYGVLITDGH RLIQIIEKPK TPLSNLVNAG IYVFKKELLN
     KIDGLSISRD FLPKLLVSDT CVSVYPYKGL WMDIGVPRDY MRINLELLTL KYPKGFISQS
     AKVSEKAELF PPFYIGDNTT VGEGSSIRNS IIGVNNRIGN GSCVEESILM NDVMLGDFSL
     IKESVIGDEV SLGKWNRVDG AIIGDGVLIH DQVFINRDTI ILPDKEVAES VYDKGKIIL