ID   MPGS_AERPE              Reviewed;         388 AA.
AC   Q9YDM5;
DT   12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Mannosyl-3-phosphoglycerate synthase;
DE            Short=MPG synthase;
DE            Short=MPGS;
DE            EC=2.4.1.217;
GN   Name=mngA; OrderedLocusNames=APE_0889.1;
OS   Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 /
OS   K1).
OC   Archaea; Crenarchaeota; Thermoprotei; Desulfurococcales;
OC   Desulfurococcaceae; Aeropyrum.
OX   NCBI_TaxID=272557;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1;
RX   PubMed=10382966; DOI=10.1093/dnares/6.2.83;
RA   Kawarabayasi Y., Hino Y., Horikawa H., Yamazaki S., Haikawa Y., Jin-no K.,
RA   Takahashi M., Sekine M., Baba S., Ankai A., Kosugi H., Hosoyama A.,
RA   Fukui S., Nagai Y., Nishijima K., Nakazawa H., Takamiya M., Masuda S.,
RA   Funahashi T., Tanaka T., Kudoh Y., Yamazaki J., Kushida N., Oguchi A.,
RA   Aoki K., Kubota K., Nakamura Y., Nomura N., Sako Y., Kikuchi H.;
RT   "Complete genome sequence of an aerobic hyper-thermophilic crenarchaeon,
RT   Aeropyrum pernix K1.";
RL   DNA Res. 6:83-101(1999).
CC   -!- FUNCTION: Transfers a mannosyl group from GDP-mannose to
CC       phosphoglycerate to form mannosyl-3-phosphoglycerate (MPG).
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-3-phosphoglycerate + GDP-alpha-D-mannose = 2-O-(alpha-D-
CC         mannosyl)-3-phosphoglycerate + GDP + H(+); Xref=Rhea:RHEA:13537,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57527, ChEBI:CHEBI:57744,
CC         ChEBI:CHEBI:58189, ChEBI:CHEBI:58272; EC=2.4.1.217;
CC   -!- PATHWAY: Carbohydrate biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate
CC       biosynthesis; 2-(alpha-D-mannosyl)-D-glycerate from GDP-alpha-D-mannose
CC       (MPG route): step 1/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. {ECO:0000305}.
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DR   EMBL; BA000002; BAA79872.2; -; Genomic_DNA.
DR   PIR; H72683; H72683.
DR   AlphaFoldDB; Q9YDM5; -.
DR   SMR; Q9YDM5; -.
DR   STRING; 272557.APE_0889.1; -.
DR   CAZy; GT55; Glycosyltransferase Family 55.
DR   EnsemblBacteria; BAA79872; BAA79872; APE_0889.1.
DR   KEGG; ape:APE_0889.1; -.
DR   eggNOG; arCOG04158; Archaea.
DR   UniPathway; UPA00130; UER00192.
DR   Proteomes; UP000002518; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050504; F:mannosyl-3-phosphoglycerate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051479; P:mannosylglycerate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR012812; Osmo_MPG_synth.
DR   Pfam; PF09488; Osmo_MPGsynth; 1.
DR   TIGRFAMs; TIGR02460; osmo_MPGsynth; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Glycosyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..388
FT                   /note="Mannosyl-3-phosphoglycerate synthase"
FT                   /id="PRO_0000059284"
SQ   SEQUENCE   388 AA;  42812 MW;  3ADC825CEB58DF05 CRC64;
     MMLSLPAKFE VFGAVRIYDV SRVLSLDGRP KSRPTNLVYV DRGELEDAAF RTVIVVPVKD
     EDLLTLENVL RSIPTESPVV VVSASTREPV DRFSNEVELA RLISRSLQRD IAIVYQFDPA
     WSEALSGTPL ESMVGASGRV RKGKGEGMLL GFIVAAALGA DFVGYVDSDN YVPGSALEYS
     WIYYSALSRA TSSYSMVRIV WPYKGKLAAS DMYLRKRGRV STITNGVLNY TLSIYKRIET
     DIIKTGNSGE QALTVKLGME MNWGSGFAVE TYQLVWMLEN CYLGLQAGKC PIAPDYIEVR
     QVSPLNPHIH AERGDEHIAE MTAVSLGTIF HSSLASEEVK SRILDQLKSL GLAEEPPKPS
     TYRPAGTDPK KVFASFIAES SDSYYFAV