MPIP1_CAEEL
ID MPIP1_CAEEL Reviewed; 604 AA.
AC O44552;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=M-phase inducer phosphatase cdc-25.1;
DE EC=3.1.3.48;
DE AltName: Full=Cell division cycle-related protein 25.1;
GN Name=cdc-25.1; ORFNames=K06A5.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP IDENTIFICATION.
RX PubMed=9651482; DOI=10.1016/s0378-1119(98)00228-5;
RA Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.;
RT "The four cdc25 genes from the nematode Caenorhabditis elegans.";
RL Gene 214:59-66(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC -!- SIMILARITY: Belongs to the MPI phosphatase family. {ECO:0000305}.
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DR EMBL; FO080960; CCD68116.1; -; Genomic_DNA.
DR PIR; T15091; T15091.
DR RefSeq; NP_491862.1; NM_059461.3.
DR AlphaFoldDB; O44552; -.
DR SMR; O44552; -.
DR BioGRID; 37805; 9.
DR DIP; DIP-25238N; -.
DR STRING; 6239.K06A5.7.1; -.
DR iPTMnet; O44552; -.
DR EPD; O44552; -.
DR PaxDb; O44552; -.
DR PeptideAtlas; O44552; -.
DR EnsemblMetazoa; K06A5.7.1; K06A5.7.1; WBGene00000386.
DR GeneID; 172353; -.
DR KEGG; cel:CELE_K06A5.7; -.
DR UCSC; K06A5.7.1; c. elegans.
DR CTD; 172353; -.
DR WormBase; K06A5.7; CE11778; WBGene00000386; cdc-25.1.
DR eggNOG; KOG3772; Eukaryota.
DR HOGENOM; CLU_452865_0_0_1; -.
DR InParanoid; O44552; -.
DR OMA; HVEYPEM; -.
DR OrthoDB; 1423329at2759; -.
DR PhylomeDB; O44552; -.
DR PRO; PR:O44552; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00000386; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0004721; F:phosphoprotein phosphatase activity; ISS:WormBase.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:WormBase.
DR GO; GO:0000212; P:meiotic spindle organization; IMP:WormBase.
DR GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0110032; P:positive regulation of G2/MI transition of meiotic cell cycle; IBA:GO_Central.
DR GO; GO:0045931; P:positive regulation of mitotic cell cycle; IMP:WormBase.
DR GO; GO:0006470; P:protein dephosphorylation; IEA:InterPro.
DR CDD; cd01530; Cdc25; 1.
DR Gene3D; 3.40.250.10; -; 1.
DR InterPro; IPR000751; MPI_Phosphatase.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR Pfam; PF00581; Rhodanese; 1.
DR PRINTS; PR00716; MPIPHPHTASE.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52821; SSF52821; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Hydrolase; Mitosis; Protein phosphatase;
KW Reference proteome.
FT CHAIN 1..604
FT /note="M-phase inducer phosphatase cdc-25.1"
FT /id="PRO_0000198655"
FT DOMAIN 305..413
FT /note="Rhodanese"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT REGION 33..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 443..464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..176
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 67892 MW; 70721C95FA9F40DC CRC64;
MATTGEKAIY EDQNNVNIIE NVVDVANGIN ESPKTLFEED GSSRDSGVSM TSCSDKSDAS
PEEDVDFSKL ESGRVALTDC SNFVSILQRN SSVSSSRSSS FYNYDTPTGR KMKTVFDLDS
LDHSEYEKRV MSERPTDNHR KRTSSSMSPS VTLLDRKRSR NLSLVAPQSD KSCRYNGLNN
PRDDPFGDED DEVFEQSNVR NSQVQNTSIF AQPAPRTATS LWDLAPPMFF ERKTSDTSGN
GSFQERPKQI LRAMSVGEID SELPPTLEVK YTLPGVDNPQ RESQAFRSIS PTTLLLEFQR
LGDDFDKKYI IVDCRFPFEY KGGHVKGAIN LFRHDKIKPI FFPENGEASS FQNRVPIFYC
EYSQKRGPTM AHAVRSIDRV LNELRYPHVE YPEMYLLDYG YKSLWSTAEC RQICEPCSYI
PMTHSSFSME FKSARLERHH SMASLKPNGE TSHREEKKKR CTRSVIRRNN SSLNMLSRSS
SALTSTGSKT SSMENILYGL DDERRPKWVS AFDIQSTESE NDLDAALIYQ RNISSNASNA
SSIVNLAEER IVQLGLQVIT PDFPDRPSES SSTTPAGEHL PLGEGGHQIP CGILDFSSIS
DDAE
