ID   MPIP3_CAEEL             Reviewed;         316 AA.
AC   P30634;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=M-phase inducer phosphatase cdc-25.3;
DE            EC=3.1.3.48;
DE   AltName: Full=Cell division cycle-related protein 25.3;
GN   Name=cdc-25.3; ORFNames=ZK637.11;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=1538779; DOI=10.1038/356037a0;
RA   Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R.,
RA   Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A.,
RA   Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R.,
RA   Waterston R.;
RT   "The C. elegans genome sequencing project: a beginning.";
RL   Nature 356:37-41(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=9651482; DOI=10.1016/s0378-1119(98)00228-5;
RA   Ashcroft N.R., Kosinski M.E., Wickramasinghe D., Donovan P.J., Golden A.;
RT   "The four cdc25 genes from the nematode Caenorhabditis elegans.";
RL   Gene 214:59-66(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC   -!- SIMILARITY: Belongs to the MPI phosphatase family. {ECO:0000305}.
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DR   EMBL; Z11115; CAA77456.1; -; Genomic_DNA.
DR   PIR; S15799; S15799.
DR   RefSeq; NP_498972.1; NM_066571.4.
DR   AlphaFoldDB; P30634; -.
DR   SMR; P30634; -.
DR   BioGRID; 41461; 2.
DR   IntAct; P30634; 2.
DR   MINT; P30634; -.
DR   STRING; 6239.ZK637.11; -.
DR   EPD; P30634; -.
DR   PaxDb; P30634; -.
DR   EnsemblMetazoa; ZK637.11.1; ZK637.11.1; WBGene00000388.
DR   GeneID; 176260; -.
DR   KEGG; cel:CELE_ZK637.11; -.
DR   UCSC; ZK637.11; c. elegans.
DR   CTD; 176260; -.
DR   WormBase; ZK637.11; CE00429; WBGene00000388; cdc-25.3.
DR   eggNOG; KOG3772; Eukaryota.
DR   GeneTree; ENSGT00970000196560; -.
DR   HOGENOM; CLU_931390_0_0_1; -.
DR   InParanoid; P30634; -.
DR   OMA; PCENCIV; -.
DR   OrthoDB; 1423329at2759; -.
DR   PhylomeDB; P30634; -.
DR   PRO; PR:P30634; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000388; Expressed in germ line (C elegans) and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0004721; F:phosphoprotein phosphatase activity; ISS:WormBase.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0000278; P:mitotic cell cycle; ISS:WormBase.
DR   GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0110032; P:positive regulation of G2/MI transition of meiotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006470; P:protein dephosphorylation; ISS:WormBase.
DR   CDD; cd01530; Cdc25; 1.
DR   Gene3D; 3.40.250.10; -; 1.
DR   InterPro; IPR000751; MPI_Phosphatase.
DR   InterPro; IPR001763; Rhodanese-like_dom.
DR   InterPro; IPR036873; Rhodanese-like_dom_sf.
DR   Pfam; PF00581; Rhodanese; 1.
DR   PRINTS; PR00716; MPIPHPHTASE.
DR   SMART; SM00450; RHOD; 1.
DR   SUPFAM; SSF52821; SSF52821; 1.
DR   PROSITE; PS50206; RHODANESE_3; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Hydrolase; Mitosis; Protein phosphatase;
KW   Reference proteome.
FT   CHAIN           1..316
FT                   /note="M-phase inducer phosphatase cdc-25.3"
FT                   /id="PRO_0000198657"
FT   DOMAIN          136..242
FT                   /note="Rhodanese"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
FT   REGION          35..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  36469 MW;  6C6EA2921623DB59 CRC64;
     MCVDVPCENC IVRNDGLRLK CSECAEGSSK LFPRQNRQHS SAISHISNSS PPTRKRSIDG
     GYTSGTDSAN TSEIVIKKRL TFSKKSHSTS EIETWNAHLQ VDYHLETVTP SCSTVYQKIT
     SETLIEIMQK LSQIEFMQKY ILIDCRYDYE YNGGHIKGAQ SLFNPETAAD FFFNKDGSKK
     INRIPIFYCE YSQKRGPTMA NNLREVDRKL NSNIYPRCDY EEIYLLEGGY KNFYAFTRGL
     EKEQRVQLCE PDNYVIMFDD RYKAELRKHQ FHKKNVSKPM KKWSSTTSVI SILTTSGTRI
     STLRQTCDPI HEHDAH