ID   MPL_MPLV                Reviewed;         184 AA.
AC   P40931;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   07-OCT-2020, entry version 77.
DE   RecName: Full=Myeloproliferative leukemia protein;
GN   Name=V-MPL;
OS   Myeloproliferative leukemia virus (MpLV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae.
OX   NCBI_TaxID=11973;
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2175677; DOI=10.1016/0092-8674(90)90410-g;
RA   Souyri M., Vigon I., Penciolelli J.-F., Heard J.-M., Tambourin P.,
RA   Wendling F.;
RT   "A putative truncated cytokine receptor gene transduced by the
RT   myeloproliferative leukemia virus immortalizes hematopoietic progenitors.";
RL   Cell 63:1137-1147(1990).
CC   -!- FUNCTION: Truncated form of the receptor for thrombopoietin.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
CC       folding and thereby efficient intracellular transport and cell-surface
CC       receptor binding.
CC   -!- DOMAIN: The box 1 motif is required for JAK interaction and/or
CC       activation.
CC   -!- MISCELLANEOUS: This protein is synthesized as an Env-Mpl polyprotein.
CC   -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M60350; AAA77654.1; -; Genomic_DNA.
DR   SMR; P40931; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   3: Inferred from homology;
KW   Membrane; Oncogene; Receptor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..184
FT                   /note="Myeloproliferative leukemia protein"
FT                   /id="PRO_0000048487"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOTIF           26..30
FT                   /note="WSXWS motif"
FT   MOTIF           80..88
FT                   /note="Box 1 motif"
SQ   SEQUENCE   184 AA;  20558 MW;  7986D3363940B735 CRC64;
     LELRPRARYS LQLRARLNGP TYQGPWSAWS PPARVSTGSE TAWITLVTAL LLVLSLSALL
     GLLLLKWQFP AHYRRLRHAL WPSLPDLHRV LGQYLRDTAA LSPSKATVTD SCEEVEPSLL
     EILPKSSEST PLPLCPSQPQ MDYRGLQPCL RTMPLSVCPP MAETGSCCTT HIANHSYLPL
     SYWQ