MPP10_SCHPO
ID MPP10_SCHPO Reviewed; 598 AA.
AC O13910;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=U3 small nucleolar ribonucleoprotein protein mpp10;
GN Name=mpp10; ORFNames=SPAC23C11.03;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-268; SER-269; SER-286 AND
RP SER-293, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Component of the U3 small nucleolar ribonucleoprotein.
CC Required for the early cleavages at sites A0, A1 and A2 during 18S
CC ribosomal pre-RNA processing (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of a heterotrimeric complex containing imp3, imp4
CC and mpp10. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MPP10 family. {ECO:0000305}.
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DR EMBL; CU329670; CAB11156.1; -; Genomic_DNA.
DR PIR; T38241; T38241.
DR RefSeq; NP_593634.1; NM_001019065.2.
DR AlphaFoldDB; O13910; -.
DR SMR; O13910; -.
DR BioGRID; 278520; 6.
DR STRING; 4896.SPAC23C11.03.1; -.
DR iPTMnet; O13910; -.
DR MaxQB; O13910; -.
DR PaxDb; O13910; -.
DR PRIDE; O13910; -.
DR EnsemblFungi; SPAC23C11.03.1; SPAC23C11.03.1:pep; SPAC23C11.03.
DR GeneID; 2542038; -.
DR KEGG; spo:SPAC23C11.03; -.
DR PomBase; SPAC23C11.03; mpp10.
DR VEuPathDB; FungiDB:SPAC23C11.03; -.
DR eggNOG; KOG2600; Eukaryota.
DR HOGENOM; CLU_011271_1_0_1; -.
DR InParanoid; O13910; -.
DR OMA; HFAEDFG; -.
DR PhylomeDB; O13910; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O13910; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0034457; C:Mpp10 complex; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0030532; C:small nuclear ribonucleoprotein complex; ISO:PomBase.
DR GO; GO:0032040; C:small-subunit processome; ISO:PomBase.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISO:PomBase.
DR GO; GO:0030490; P:maturation of SSU-rRNA; ISO:PomBase.
DR InterPro; IPR012173; Mpp10.
DR PANTHER; PTHR17039; PTHR17039; 1.
DR Pfam; PF04006; Mpp10; 1.
DR PIRSF; PIRSF017300; snoRNP_Mpp10; 1.
PE 1: Evidence at protein level;
KW Nucleus; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosome biogenesis; rRNA processing.
FT CHAIN 1..598
FT /note="U3 small nucleolar ribonucleoprotein protein mpp10"
FT /id="PRO_0000121533"
FT REGION 76..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 284..303
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..598
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..116
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..146
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..212
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..269
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 509..525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..546
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 268
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 269
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 286
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 293
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 598 AA; 67707 MW; 36439BA7106FEF99 CRC64;
MTELINSEPT LFLFPNKEDS KQLVEKAIEV FSNIKIPSTS PIQTIVTKGL DNWQIYNQLA
LAAKYALDDL PQVDVENEDE EEDSITSFQD EDDETSHQEL SDNSEMNNRD DADDEFLGFS
GPENLEDVDE SSAEDVSGDE AEIMNEEGQQ IEQKKDAFGL NDGFFDIDNF NKQTLALEEE
AVEEGVLGDE DDGIDLLMDP DENMEDSEDE SNGPQADSIM YEDFFGPKTA AGRRELKKKK
AESKRKRTSK PDFKNDVQQN VIEENNESSD NEYATFDRVK KDLFASDEED DVSADQLSSY
ERDKARLTQQ IRELEAENVA KKSWTMMGEA TSKGRPSNSL LDVDLEFETG AKPVPVQTEE
TTETLEDLIK NRIISKTFDD VPKRAPVAVT EFRPSELFEL NENKSQRSLA EEYEEEFLKK
SNADTYKSEA DKKKEKEHEE IKALFSEVSR TLDSLASWHY VPPPPESTVE IVSNAPTLAM
EDVQPTAASD TMALAPQEVY KPSNENREGE TITRSGIAIS STEMDHQQKQ ARRRRVRRKH
AEKRKQMAEK RRNSGTEQVV RQLSKSNVEV IGKGGERKKV ASNSNKYHPI VSSNQLKL
