ARNE_PSEA7
ID ARNE_PSEA7 Reviewed; 115 AA.
AC A6V1N7;
DT 01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE {ECO:0000255|HAMAP-Rule:MF_01869};
DE Short=L-Ara4N-phosphoundecaprenol flippase subunit ArnE {ECO:0000255|HAMAP-Rule:MF_01869};
DE AltName: Full=Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE {ECO:0000255|HAMAP-Rule:MF_01869};
GN Name=arnE {ECO:0000255|HAMAP-Rule:MF_01869}; OrderedLocusNames=PSPA7_1588;
OS Pseudomonas aeruginosa (strain PA7).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=381754;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PA7;
RA Dodson R.J., Harkins D., Paulsen I.T.;
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol
CC (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the
CC periplasmic side of the inner membrane. {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01869}.
CC -!- SUBUNIT: Heterodimer of ArnE and ArnF. {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01869}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
CC -!- SIMILARITY: Belongs to the ArnE family. {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
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DR EMBL; CP000744; ABR85603.1; -; Genomic_DNA.
DR RefSeq; WP_012074755.1; NC_009656.1.
DR AlphaFoldDB; A6V1N7; -.
DR EnsemblBacteria; ABR85603; ABR85603; PSPA7_1588.
DR KEGG; pap:PSPA7_1588; -.
DR HOGENOM; CLU_131462_5_1_6; -.
DR OMA; TCAGQLC; -.
DR OrthoDB; 1944417at2; -.
DR UniPathway; UPA00030; -.
DR Proteomes; UP000001582; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1901505; F:carbohydrate derivative transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR HAMAP; MF_01869; Flippase_ArnE; 1.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR022883; Flippase_ArnE.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00892; EamA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Lipid A biosynthesis;
KW Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis;
KW Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..115
FT /note="Probable 4-amino-4-deoxy-L-arabinose-
FT phosphoundecaprenol flippase subunit ArnE"
FT /id="PRO_0000382983"
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
FT DOMAIN 46..113
FT /note="EamA"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
SQ SEQUENCE 115 AA; 12493 MW; A30D24E2D5823889 CRC64;
MSAALLLATL LMTGLGQVAQ KLTVEHWRLV AADGWAARLR SPWPWLALLA LGLGLACWLL
LLQRVEVGSA YPMLALNFVL VTLVARFVFD EPVDRRHLAG LLLIVAGVAL LGRQA
