MPP3_HUMAN
ID MPP3_HUMAN Reviewed; 585 AA.
AC Q13368; B2R7N0; D3DX47; Q4GX05; Q6PGR3; Q86SV1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 174.
DE RecName: Full=MAGUK p55 subfamily member 3;
DE AltName: Full=Discs large homolog 3;
DE AltName: Full=Protein MPP3;
GN Name=MPP3; Synonyms=DLG3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8824795; DOI=10.1006/geno.1996.0025;
RA Smith S.A., Holik P., Stevens J., Mazoyer S., Melis R., Williams B.,
RA White R., Albertsen H.;
RT "Isolation of a gene (DLG3) encoding a second member of the discs-large
RT family on chromosome 17q12-q21.";
RL Genomics 31:145-150(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Retina;
RA Kantardzhieva A., Alexeeva S., Versteeg I., de Jong P.T.V.M., Wijnholds J.;
RT "Human retinal membrane palmitoylated protein 3 (mpp3): molecular cloning
RT and characterization.";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INTERACTION WITH CADM1.
RX PubMed=13679854; DOI=10.1038/sj.onc.1206744;
RA Fukuhara H., Masuda M., Yageta M., Fukami T., Kuramochi M., Maruyama T.,
RA Kitamura T., Murakami Y.;
RT "Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue
RT of Drosophila tumor suppressor Dlg.";
RL Oncogene 22:6160-6165(2003).
CC -!- SUBUNIT: May interact with HTR2A (By similarity). Interacts (via PDZ
CC domain) with CADM1 (via C-terminus). Interacts with HTR4 (By
CC similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q13368; Q9H0C5: BTBD1; NbExp=3; IntAct=EBI-716157, EBI-935503;
CC Q13368; O14910: LIN7A; NbExp=5; IntAct=EBI-716157, EBI-2513988;
CC Q13368; Q9HAP6: LIN7B; NbExp=8; IntAct=EBI-716157, EBI-821335;
CC Q13368; Q9NUP9: LIN7C; NbExp=7; IntAct=EBI-716157, EBI-1171517;
CC Q13368; P55347: PKNOX1; NbExp=3; IntAct=EBI-716157, EBI-1373569;
CC Q13368; Q8N720: ZNF655; NbExp=3; IntAct=EBI-716157, EBI-625509;
CC -!- SIMILARITY: Belongs to the MAGUK family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH47017.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U37707; AAB36964.1; -; mRNA.
DR EMBL; AM050144; CAJ18313.1; -; mRNA.
DR EMBL; AM050145; CAJ18315.1; -; mRNA.
DR EMBL; AK313045; BAG35877.1; -; mRNA.
DR EMBL; CH471178; EAW51664.1; -; Genomic_DNA.
DR EMBL; CH471178; EAW51665.1; -; Genomic_DNA.
DR EMBL; BC047017; AAH47017.1; ALT_INIT; mRNA.
DR EMBL; BC056865; AAH56865.1; -; mRNA.
DR CCDS; CCDS42344.1; -.
DR PIR; G02165; G02165.
DR RefSeq; NP_001317162.1; NM_001330233.1.
DR RefSeq; NP_001923.2; NM_001932.4.
DR RefSeq; XP_006721978.1; XM_006721915.2.
DR AlphaFoldDB; Q13368; -.
DR SMR; Q13368; -.
DR BioGRID; 110496; 34.
DR CORUM; Q13368; -.
DR IntAct; Q13368; 34.
DR STRING; 9606.ENSP00000381425; -.
DR iPTMnet; Q13368; -.
DR PhosphoSitePlus; Q13368; -.
DR BioMuta; MPP3; -.
DR DMDM; 150421601; -.
DR jPOST; Q13368; -.
DR MassIVE; Q13368; -.
DR MaxQB; Q13368; -.
DR PaxDb; Q13368; -.
DR PeptideAtlas; Q13368; -.
DR PRIDE; Q13368; -.
DR ProteomicsDB; 59353; -.
DR Antibodypedia; 8160; 323 antibodies from 28 providers.
DR DNASU; 4356; -.
DR Ensembl; ENST00000398389.9; ENSP00000381425.4; ENSG00000161647.19.
DR GeneID; 4356; -.
DR KEGG; hsa:4356; -.
DR MANE-Select; ENST00000398389.9; ENSP00000381425.4; NM_001932.6; NP_001923.2.
DR UCSC; uc002iei.5; human.
DR CTD; 4356; -.
DR DisGeNET; 4356; -.
DR GeneCards; MPP3; -.
DR HGNC; HGNC:7221; MPP3.
DR HPA; ENSG00000161647; Group enriched (brain, heart muscle).
DR MIM; 601114; gene.
DR neXtProt; NX_Q13368; -.
DR OpenTargets; ENSG00000161647; -.
DR PharmGKB; PA30926; -.
DR VEuPathDB; HostDB:ENSG00000161647; -.
DR eggNOG; KOG0609; Eukaryota.
DR GeneTree; ENSGT00940000157190; -.
DR HOGENOM; CLU_001715_5_0_1; -.
DR InParanoid; Q13368; -.
DR OMA; EGYFKGH; -.
DR OrthoDB; 531106at2759; -.
DR PhylomeDB; Q13368; -.
DR TreeFam; TF314263; -.
DR PathwayCommons; Q13368; -.
DR SignaLink; Q13368; -.
DR BioGRID-ORCS; 4356; 23 hits in 1071 CRISPR screens.
DR GenomeRNAi; 4356; -.
DR Pharos; Q13368; Tbio.
DR PRO; PR:Q13368; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q13368; protein.
DR Bgee; ENSG00000161647; Expressed in apex of heart and 127 other tissues.
DR ExpressionAtlas; Q13368; baseline and differential.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR CDD; cd12039; SH3_MPP3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR035604; MPP3_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; SSF101288; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..585
FT /note="MAGUK p55 subfamily member 3"
FT /id="PRO_0000094575"
FT DOMAIN 6..60
FT /note="L27 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT DOMAIN 61..118
FT /note="L27 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT DOMAIN 137..212
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 226..296
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 385..570
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00100"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O88954"
FT VARIANT 585
FT /note="R -> G (in dbSNP:rs17742683)"
FT /id="VAR_050014"
FT CONFLICT 37
FT /note="V -> D (in Ref. 1; AAB36964)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 585 AA; 66152 MW; 782DAE54096A4993 CRC64;
MPVLSEDSGL HETLALLTSQ LRPDSNHKEE MGFLRDVFSE KSLSYLMKIH EKLRYYERQS
PTPVLHSAVA LAEDVMEELQ AASVHSDERE LLQLLSTPHL RAVLMVHDTV AQKNFDPVLP
PLPDNIDEDF DEESVKIVRL VKNKEPLGAT IRRDEHSGAV VVARIMRGGA ADRSGLVHVG
DELREVNGIA VLHKRPDEIS QILAQSQGSI TLKIIPATQE EDRLKESKVF MRALFHYNPR
EDRAIPCQEA GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKG FQERRLSYRR
AAGTLPSPQS LRKPPYDQPC DKETCDCEGY LKGHYVAGLR RSFRLGCRER LGGSQEGKMS
SGAESPELLT YEEVARYQHQ PGERPRLVVL IGSLGARLHE LKQKVVAENP QHFGVAVPHT
TRPRKSHEKE GVEYHFVSKQ AFEADLHHNK FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL
VDVEPEALKQ LRTSEFKPYI IFVKPAIQEK RKTPPMSPAC EDTAAPFDEQ QQEMAASAAF
IDRHYGHLVD AVLVKEDLQG AYSQLKVVLE KLSKDTHWVP VSWVR
