MPP3_MOUSE
ID MPP3_MOUSE Reviewed; 568 AA.
AC O88910; E9Q5S2;
DT 10-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 25-MAY-2022, entry version 137.
DE RecName: Full=MAGUK p55 subfamily member 3;
DE AltName: Full=Discs large homolog 3;
DE AltName: Full=Protein MPP3;
GN Name=Mpp3; Synonyms=Dlgh3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=9838122; DOI=10.1016/s0167-4781(98)00209-7;
RA Lin L., Peters L.L., Ciciotte S.L., Chishti A.H.;
RT "cDNA sequence and chromosomal localization of mouse Dlgh3 gene adjacent to
RT the BRCA1 tumor suppressor locus.";
RL Biochim. Biophys. Acta 1443:211-216(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP INTERACTION WITH HTR2A.
RX PubMed=14988405; DOI=10.1074/jbc.m312106200;
RA Becamel C., Gavarini S., Chanrion B., Alonso G., Galeotti N., Dumuis A.,
RA Bockaert J., Marin P.;
RT "The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of
RT PDZ proteins.";
RL J. Biol. Chem. 279:20257-20266(2004).
RN [4]
RP INTERACTION WITH HTR4.
RX PubMed=15466885; DOI=10.1242/jcs.01379;
RA Joubert L., Hanson B., Barthet G., Sebben M., Claeysen S., Hong W.,
RA Marin P., Dumuis A., Bockaert J.;
RT "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a
RT receptor splice variant: roles in receptor targeting.";
RL J. Cell Sci. 117:5367-5379(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: May interact with HTR2A. Interacts (via PDZ domain) with CADM1
CC (via C-terminus). Interacts with HTR4. {ECO:0000269|PubMed:14988405,
CC ECO:0000269|PubMed:15466885}.
CC -!- TISSUE SPECIFICITY: Expressed in brain, skeletal muscle, testis,
CC kidney, and lung.
CC -!- SIMILARITY: Belongs to the MAGUK family. {ECO:0000305}.
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DR EMBL; AF079366; AAD12762.1; -; mRNA.
DR EMBL; AL591145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; O88910; -.
DR SMR; O88910; -.
DR STRING; 10090.ENSMUSP00000055469; -.
DR iPTMnet; O88910; -.
DR PhosphoSitePlus; O88910; -.
DR MaxQB; O88910; -.
DR PaxDb; O88910; -.
DR PeptideAtlas; O88910; -.
DR PRIDE; O88910; -.
DR ProteomicsDB; 291489; -.
DR MGI; MGI:1328354; Mpp3.
DR eggNOG; KOG0609; Eukaryota.
DR InParanoid; O88910; -.
DR ChiTaRS; Mpp3; mouse.
DR PRO; PR:O88910; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O88910; protein.
DR GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030165; F:PDZ domain binding; ISO:MGI.
DR CDD; cd12039; SH3_MPP3; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR035604; MPP3_SH3.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; SSF101288; 1.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50002; SH3; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..568
FT /note="MAGUK p55 subfamily member 3"
FT /id="PRO_0000094576"
FT DOMAIN 6..60
FT /note="L27 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT DOMAIN 61..118
FT /note="L27 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT DOMAIN 137..218
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT DOMAIN 226..296
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 385..568
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00100"
FT MOD_RES 307
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:O88954"
FT CONFLICT 3
FT /note="V -> I (in Ref. 1; AAD12762)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="G -> E (in Ref. 1; AAD12762)"
FT /evidence="ECO:0000305"
FT CONFLICT 429
FT /note="R -> I (in Ref. 1; AAD12762)"
FT /evidence="ECO:0000305"
FT CONFLICT 450
FT /note="K -> R (in Ref. 1; AAD12762)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 568 AA; 64401 MW; 078EC699D9DB0C93 CRC64;
MPVLSEDSGL HETLALLTSQ LRPDSNHREE MGFLRDVFSE KSLSYLMKIH EKLRYYERQS
PTPVLHSAMA LAEDVMEELQ AASVHSDERE LLQLLSTPHL RAVLMVHDTV AQKNFDPVLP
PLPDNIDEDF EEESVKIVRL VKNKEPLGAT IRRDEHSGAV VVARIMRGGA ADRSGLVHVG
DELREVNGIA VLHKRPDEIS QILAQSQGSI TLKIIPATQE EDRFKDSKVF MRALFHYDPR
EDRAIPCQEA GLPFQRRQVL EVVSQDDPTW WQAKRVGDTN LRAGLIPSKQ FQERRLSYRR
TTGTLPSPQN FKKPPYDQPC DKETCDCDGY FKGHYVAGLR RSFRLGCRER LGGSQEAKVP
TGAESQVLLT YEEVARYQHQ PGERPRLVVL IGSLGAHLHE LKQRVVAEDP QQFAVAVPHT
TRPRKSHERD GVEYHFVSKQ AFEADVHHNK FLEHGEYKEN LYGTSLEAIQ AVMAKNKVCL
VDVEPEALRH LRTPEFKPYV IFVKPAIQER RKTPPVSPDS EDIASSLDEQ QQEMAASAAF
IDQHYGHLID TVLVRQDLQE PAASSELS
