ID   MPP4_RAT                Reviewed;         441 AA.
AC   Q9QYH1; Q9QYG9; Q9QYH0;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=MAGUK p55 subfamily member 4;
DE   AltName: Full=Discs large homolog 6;
DE            Short=rDLG6;
GN   Name=Mpp4; Synonyms=Dlg6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, AND
RP   INTERACTION WITH GRIA2.
RC   STRAIN=Sprague-Dawley; TISSUE=Cerebellum;
RX   PubMed=10558890; DOI=10.1006/bbrc.1999.1723;
RA   Inagaki H., Maeda S., Lin K.H., Shimizu N., Saito T.;
RT   "rDLG6: a novel homolog of Drosophila DLG expressed in rat brain.";
RL   Biochem. Biophys. Res. Commun. 265:462-468(1999).
CC   -!- FUNCTION: May play a role in retinal photoreceptors development.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with MPDZ (By similarity). May interact with GRIA2.
CC       Forms a complex with CRB1 and PALS1. Interacts with FASLG (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=Localized at photoreceptor
CC       synaptic terminals in retina. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=Alpha;
CC         IsoId=Q9QYH1-1; Sequence=Displayed;
CC       Name=2; Synonyms=Beta;
CC         IsoId=Q9QYH1-2; Sequence=VSP_014001;
CC       Name=3; Synonyms=Gamma;
CC         IsoId=Q9QYH1-3; Sequence=VSP_014000;
CC   -!- TISSUE SPECIFICITY: Highly expressed in brain and detected in lung, and
CC       bone (at protein level). Also expressed in intestine and spleen.
CC       {ECO:0000269|PubMed:10558890}.
CC   -!- SIMILARITY: Belongs to the MAGUK family. {ECO:0000305}.
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DR   EMBL; AB030499; BAA88229.1; -; mRNA.
DR   EMBL; AB030500; BAA88230.1; -; mRNA.
DR   EMBL; AB030501; BAA88231.1; -; mRNA.
DR   AlphaFoldDB; Q9QYH1; -.
DR   SMR; Q9QYH1; -.
DR   IntAct; Q9QYH1; 3.
DR   STRING; 10116.ENSRNOP00000014094; -.
DR   PaxDb; Q9QYH1; -.
DR   UCSC; RGD:620016; rat. [Q9QYH1-1]
DR   RGD; 620016; Mpp4.
DR   eggNOG; KOG0609; Eukaryota.
DR   InParanoid; Q9QYH1; -.
DR   PRO; PR:Q9QYH1; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005912; C:adherens junction; ISO:RGD.
DR   GO; GO:0045178; C:basal part of cell; ISO:RGD.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0044316; C:cone cell pedicle; ISO:RGD.
DR   GO; GO:0000139; C:Golgi membrane; ISO:RGD.
DR   GO; GO:0016328; C:lateral plasma membrane; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042734; C:presynaptic membrane; ISO:RGD.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0044317; C:rod spherule; ISO:RGD.
DR   GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB.
DR   GO; GO:0035418; P:protein localization to synapse; ISO:RGD.
DR   CDD; cd12034; SH3_MPP4; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR035600; MPP4_SH3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Reference proteome;
KW   SH3 domain.
FT   CHAIN           1..441
FT                   /note="MAGUK p55 subfamily member 4"
FT                   /id="PRO_0000094579"
FT   DOMAIN          1..84
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          91..161
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          232..421
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00100"
FT   COILED          373..430
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         181..441
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:10558890"
FT                   /id="VSP_014000"
FT   VAR_SEQ         334..351
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10558890"
FT                   /id="VSP_014001"
SQ   SEQUENCE   441 AA;  50052 MW;  EB5F0711B4AC7CD6 CRC64;
     MRTVCLVKNQ QPLGATIKRH EITGDILVAR VIHGGLVERN GLLYAGDKLV EVNGVPVEGL
     DPEQVIHILA MSCGTIMFKV IPVSAPPVSS QTTVYVRAMI DYWPQEDPDI PCMDAGLPFL
     KGDILQIVDQ SDALWWQARK ISDIAICAGL IPSNHLLKRK QREFWWSQPY QPHTCLKSTR
     SKEEFVGDGQ QFFIAGFRQQ HANMRCTCSC YSAVGAPYEE VVRYQRQPAD KHRLIVLVGP
     SGVGVNELRR QLIGCNPSCF QSAVPHTTRS PKSYEMDGRE YHYVSRETFE SLMYGHRMLE
     FGEYKGHLYG TSVNAVLAVL DEGKICVMDL EPQDIQLART RELKPYVIFI KPPSMSSMRH
     SRRNAKIITD YFVDMKFKDE DLQEMEELAQ KMESQFGQFF DHVIVNDNLQ DARAQLLSAI
     QKAEEELQWV PEAWVSPGAE S