ID   MPP7_XENTR              Reviewed;         576 AA.
AC   A8KBF6;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=MAGUK p55 subfamily member 7;
GN   Name=mpp7;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as an important adapter that promotes epithelial cell
CC       polarity and tight junction formation. Involved in the assembly of
CC       protein complexes at sites of cell-cell contact (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
CC       Cell junction, adherens junction {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MAGUK family. {ECO:0000305}.
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DR   EMBL; BC154093; AAI54094.1; -; mRNA.
DR   RefSeq; NP_001106472.1; NM_001113001.1.
DR   AlphaFoldDB; A8KBF6; -.
DR   SMR; A8KBF6; -.
DR   PaxDb; A8KBF6; -.
DR   ABCD; A8KBF6; 1 sequenced antibody.
DR   GeneID; 100127657; -.
DR   KEGG; xtr:100127657; -.
DR   CTD; 143098; -.
DR   Xenbase; XB-GENE-950404; mpp7.
DR   eggNOG; KOG0609; Eukaryota.
DR   HOGENOM; CLU_001715_5_0_1; -.
DR   InParanoid; A8KBF6; -.
DR   OMA; CDMLAAV; -.
DR   OrthoDB; 531106at2759; -.
DR   TreeFam; TF314263; -.
DR   Reactome; R-XTR-9013149; RAC1 GTPase cycle.
DR   Reactome; R-XTR-9013404; RAC2 GTPase cycle.
DR   Reactome; R-XTR-9013406; RHOQ GTPase cycle.
DR   Reactome; R-XTR-9013409; RHOJ GTPase cycle.
DR   Reactome; R-XTR-9013423; RAC3 GTPase cycle.
DR   Proteomes; UP000008143; Chromosome 6.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000004546; Expressed in skeletal muscle tissue and 12 other tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0071896; P:protein localization to adherens junction; IBA:GO_Central.
DR   CDD; cd12033; SH3_MPP7; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR008145; GK/Ca_channel_bsu.
DR   InterPro; IPR008144; Guanylate_kin-like_dom.
DR   InterPro; IPR020590; Guanylate_kinase_CS.
DR   InterPro; IPR014775; L27_C.
DR   InterPro; IPR004172; L27_dom.
DR   InterPro; IPR036892; L27_dom_sf.
DR   InterPro; IPR035599; MPP7_SH3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   Pfam; PF00625; Guanylate_kin; 1.
DR   Pfam; PF02828; L27; 2.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00072; GuKc; 1.
DR   SMART; SM00569; L27; 2.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF101288; SSF101288; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR   PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR   PROSITE; PS51022; L27; 2.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Membrane; Reference proteome; Repeat; SH3 domain;
KW   Tight junction.
FT   CHAIN           1..576
FT                   /note="MAGUK p55 subfamily member 7"
FT                   /id="PRO_0000320031"
FT   DOMAIN          10..63
FT                   /note="L27 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT   DOMAIN          65..122
FT                   /note="L27 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00365"
FT   DOMAIN          139..220
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT   DOMAIN          228..298
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   DOMAIN          368..560
FT                   /note="Guanylate kinase-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00100"
SQ   SEQUENCE   576 AA;  65544 MW;  419B93949631EA83 CRC64;
     MPALSTGAGS DTGLYEILAT LPAQLQPHVD SQEDLTFLWD MFGEKSLHSL VKIHEKLHYY
     EKENPMPVIH SATALAEELA EELQSKSLNS EIRELLKLLS KPNLKALLSV HDTVAQKSYD
     PVLPPMPDDI DDDEDSVKII RLVKNREPLG ATIKKDEKTG AIVVARIMRG GAADRSGLIH
     VGDELREVNG ISVEDKKPEE IIHILAQSQG AITFKIIPSI KEEPPNNDGK MFVKALFDYY
     PNEDKAIPCK EAGLSFRKGD ILQIMSQDDA TWWQAKHEGD ANPRAGLIPS KQFQERRFAL
     RKPVVSNQPQ KVPNRKSSGF RRSFRLSRKD RKTNKFMYEC KKSDQYDTAD VPTYEEVALY
     QRKPNEKYRL VILVGPVGVG VNELKRKVLI GNSQHYGVTV PHTTRGKRSQ ENDGVEYIFI
     SKHLFETDIH NNKFIEYGEY KNNYYGTSLD SVRSVLAKNK ICLLDVQPNS LKHLRTSEFK
     PFVIFIKPPT IERLRETRRN AKVISGKDER GAAKPFSDED FEEMIQSAEA MEAQYDHFFD
     TTIVNDDLSA AYNELRSTLE RLEMEGFWVP VSWLHS