MPPD1_HUMAN
ID MPPD1_HUMAN Reviewed; 326 AA.
AC O15442; A8K159; B7Z2S9; Q8N361;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Metallophosphoesterase domain-containing protein 1;
DE EC=3.1.-.-;
DE AltName: Full=Adult brain protein 239;
DE Short=239AB;
GN Name=MPPED1; Synonyms=C22orf1, FAM1A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9266672; DOI=10.1016/s0378-1119(97)00149-2;
RA Schwartz F., Ota T.;
RT "The 239AB gene on chromosome 22: a novel member of an ancient gene
RT family.";
RL Gene 194:57-62(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May have metallophosphoesterase activity (in vitro).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC O15442-2; Q9BSU1: PHAF1; NbExp=3; IntAct=EBI-12183511, EBI-946080;
CC O15442-2; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-12183511, EBI-527853;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=O15442-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O15442-2; Sequence=VSP_056871;
CC -!- TISSUE SPECIFICITY: Expressed predominantly in adult brain.
CC -!- SIMILARITY: Belongs to the UPF0046 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC51673.2; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U84894; AAC51673.2; ALT_FRAME; mRNA.
DR EMBL; AK289774; BAF82463.1; -; mRNA.
DR EMBL; AK290541; BAF83230.1; -; mRNA.
DR EMBL; AK294912; BAG57999.1; -; mRNA.
DR EMBL; AK295077; BAH11965.1; -; mRNA.
DR EMBL; CU137653; CAQ06857.1; -; Genomic_DNA.
DR EMBL; AL049708; CAQ06857.1; JOINED; Genomic_DNA.
DR EMBL; AL096759; CAQ06857.1; JOINED; Genomic_DNA.
DR EMBL; BX546033; CAQ06857.1; JOINED; Genomic_DNA.
DR EMBL; CR377231; CAQ06857.1; JOINED; Genomic_DNA.
DR EMBL; Z82172; CAQ06857.1; JOINED; Genomic_DNA.
DR EMBL; AL049708; CAQ08121.1; -; Genomic_DNA.
DR EMBL; AL096759; CAQ08121.1; JOINED; Genomic_DNA.
DR EMBL; BX546033; CAQ08121.1; JOINED; Genomic_DNA.
DR EMBL; CR377231; CAQ08121.1; JOINED; Genomic_DNA.
DR EMBL; CU137653; CAQ08121.1; JOINED; Genomic_DNA.
DR EMBL; Z82172; CAQ08121.1; JOINED; Genomic_DNA.
DR EMBL; CR377231; CAQ08182.1; -; Genomic_DNA.
DR EMBL; AL049708; CAQ08182.1; JOINED; Genomic_DNA.
DR EMBL; AL096759; CAQ08182.1; JOINED; Genomic_DNA.
DR EMBL; BX546033; CAQ08182.1; JOINED; Genomic_DNA.
DR EMBL; CU137653; CAQ08182.1; JOINED; Genomic_DNA.
DR EMBL; Z82172; CAQ08182.1; JOINED; Genomic_DNA.
DR EMBL; BX546033; CAQ08847.1; -; Genomic_DNA.
DR EMBL; AL049708; CAQ08847.1; JOINED; Genomic_DNA.
DR EMBL; AL096759; CAQ08847.1; JOINED; Genomic_DNA.
DR EMBL; CR377231; CAQ08847.1; JOINED; Genomic_DNA.
DR EMBL; CU137653; CAQ08847.1; JOINED; Genomic_DNA.
DR EMBL; Z82172; CAQ08847.1; JOINED; Genomic_DNA.
DR EMBL; Z82172; CAQ10809.1; -; Genomic_DNA.
DR EMBL; AL049708; CAQ10809.1; JOINED; Genomic_DNA.
DR EMBL; AL096759; CAQ10809.1; JOINED; Genomic_DNA.
DR EMBL; BX546033; CAQ10809.1; JOINED; Genomic_DNA.
DR EMBL; CR377231; CAQ10809.1; JOINED; Genomic_DNA.
DR EMBL; CU137653; CAQ10809.1; JOINED; Genomic_DNA.
DR EMBL; BC028035; AAH28035.1; -; mRNA.
DR CCDS; CCDS46723.1; -. [O15442-1]
DR RefSeq; NP_001037835.1; NM_001044370.1. [O15442-1]
DR RefSeq; XP_011528669.1; XM_011530367.2.
DR AlphaFoldDB; O15442; -.
DR SMR; O15442; -.
DR BioGRID; 107213; 41.
DR IntAct; O15442; 23.
DR MINT; O15442; -.
DR STRING; 9606.ENSP00000388137; -.
DR PhosphoSitePlus; O15442; -.
DR BioMuta; MPPED1; -.
DR MassIVE; O15442; -.
DR PaxDb; O15442; -.
DR PeptideAtlas; O15442; -.
DR PRIDE; O15442; -.
DR ProteomicsDB; 48671; -. [O15442-1]
DR ProteomicsDB; 6458; -.
DR Antibodypedia; 27528; 133 antibodies from 19 providers.
DR DNASU; 758; -.
DR Ensembl; ENST00000417669.6; ENSP00000388137.1; ENSG00000186732.14. [O15442-1]
DR Ensembl; ENST00000443721.2; ENSP00000400686.1; ENSG00000186732.14. [O15442-1]
DR GeneID; 758; -.
DR KEGG; hsa:758; -.
DR MANE-Select; ENST00000443721.2; ENSP00000400686.1; NM_001044370.2; NP_001037835.1.
DR UCSC; uc011apv.3; human. [O15442-1]
DR CTD; 758; -.
DR DisGeNET; 758; -.
DR GeneCards; MPPED1; -.
DR HGNC; HGNC:1306; MPPED1.
DR HPA; ENSG00000186732; Group enriched (brain, liver).
DR MIM; 602112; gene.
DR neXtProt; NX_O15442; -.
DR OpenTargets; ENSG00000186732; -.
DR PharmGKB; PA25880; -.
DR VEuPathDB; HostDB:ENSG00000186732; -.
DR eggNOG; KOG3947; Eukaryota.
DR GeneTree; ENSGT00390000007681; -.
DR HOGENOM; CLU_041441_1_0_1; -.
DR InParanoid; O15442; -.
DR OMA; KTRICMI; -.
DR OrthoDB; 1301937at2759; -.
DR PhylomeDB; O15442; -.
DR TreeFam; TF314305; -.
DR PathwayCommons; O15442; -.
DR SignaLink; O15442; -.
DR BioGRID-ORCS; 758; 8 hits in 1064 CRISPR screens.
DR ChiTaRS; MPPED1; human.
DR GenomeRNAi; 758; -.
DR Pharos; O15442; Tdark.
DR PRO; PR:O15442; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; O15442; protein.
DR Bgee; ENSG00000186732; Expressed in cortical plate and 90 other tissues.
DR ExpressionAtlas; O15442; baseline and differential.
DR Genevisible; O15442; HS.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.60.21.10; -; 1.
DR InterPro; IPR024201; Calcineurin-like_Pesterase.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR Pfam; PF00149; Metallophos; 1.
DR PIRSF; PIRSF035808; Pdiesterase_Brain_239; 1.
DR SUPFAM; SSF56300; SSF56300; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Hydrolase; Reference proteome.
FT CHAIN 1..326
FT /note="Metallophosphoesterase domain-containing protein 1"
FT /id="PRO_0000053403"
FT VAR_SEQ 1
FT /note="M -> MNGRETQSVSRSGGGPGCGGGSGGRCRGGRRRSM (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056871"
SQ SEQUENCE 326 AA; 37207 MW; 462265716D3AA1E2 CRC64;
MWRSRWDASV LKAEALALLP CGLGMAFSQS HVMAARRHQH SRLIIEVDEY SSNPTQAFTF
YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS RTDPIQMPYG DVLIHAGDFT
ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN
YENVQSLLTN CIYLQDSEVT VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD
ILITHGPPLG FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV
NASVCTVNYQ PVNPPIVIDL PTPRNS
