ID   MPPD1_MOUSE             Reviewed;         326 AA.
AC   Q91ZG2; A6PW09; Q3TMS4; Q3TYC7;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Metallophosphoesterase domain-containing protein 1;
DE            EC=3.1.-.-;
GN   Name=Mpped1; Synonyms=D15Bwg0669e;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic brain, Embryonic head, and Visual cortex;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryonic brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May have metallophosphoesterase activity (in vitro).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0046 family. {ECO:0000305}.
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DR   EMBL; AK048421; BAC33331.1; -; mRNA.
DR   EMBL; AK158740; BAE34636.1; -; mRNA.
DR   EMBL; AK165755; BAE38367.1; -; mRNA.
DR   EMBL; AL513354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC057550; AAH57550.1; -; mRNA.
DR   CCDS; CCDS37164.1; -.
DR   RefSeq; NP_766198.1; NM_172610.3.
DR   RefSeq; XP_006520880.1; XM_006520817.3.
DR   RefSeq; XP_006520881.1; XM_006520818.3.
DR   RefSeq; XP_006520882.1; XM_006520819.2.
DR   RefSeq; XP_006520883.1; XM_006520820.3.
DR   RefSeq; XP_017172062.1; XM_017316573.1.
DR   AlphaFoldDB; Q91ZG2; -.
DR   SMR; Q91ZG2; -.
DR   STRING; 10090.ENSMUSP00000041981; -.
DR   iPTMnet; Q91ZG2; -.
DR   PhosphoSitePlus; Q91ZG2; -.
DR   MaxQB; Q91ZG2; -.
DR   PaxDb; Q91ZG2; -.
DR   PRIDE; Q91ZG2; -.
DR   ProteomicsDB; 290307; -.
DR   Antibodypedia; 27528; 133 antibodies from 19 providers.
DR   DNASU; 223726; -.
DR   Ensembl; ENSMUST00000046168; ENSMUSP00000041981; ENSMUSG00000041708.
DR   Ensembl; ENSMUST00000109470; ENSMUSP00000105096; ENSMUSG00000041708.
DR   GeneID; 223726; -.
DR   KEGG; mmu:223726; -.
DR   UCSC; uc007xbk.1; mouse.
DR   CTD; 758; -.
DR   MGI; MGI:106316; Mpped1.
DR   VEuPathDB; HostDB:ENSMUSG00000041708; -.
DR   eggNOG; KOG3947; Eukaryota.
DR   GeneTree; ENSGT00390000007681; -.
DR   HOGENOM; CLU_041441_1_0_1; -.
DR   InParanoid; Q91ZG2; -.
DR   OMA; KTRICMI; -.
DR   OrthoDB; 1301937at2759; -.
DR   PhylomeDB; Q91ZG2; -.
DR   TreeFam; TF314305; -.
DR   BioGRID-ORCS; 223726; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Mpped1; mouse.
DR   PRO; PR:Q91ZG2; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q91ZG2; protein.
DR   Bgee; ENSMUSG00000041708; Expressed in cortical plate and 54 other tissues.
DR   ExpressionAtlas; Q91ZG2; baseline and differential.
DR   Genevisible; Q91ZG2; MM.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR024201; Calcineurin-like_Pesterase.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   Pfam; PF00149; Metallophos; 1.
DR   PIRSF; PIRSF035808; Pdiesterase_Brain_239; 1.
DR   SUPFAM; SSF56300; SSF56300; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Metallophosphoesterase domain-containing protein 1"
FT                   /id="PRO_0000053404"
FT   CONFLICT        183
FT                   /note="N -> D (in Ref. 1; BAE38367)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   326 AA;  37214 MW;  1ED68BD4F424BAD9 CRC64;
     MWRPRWDPGI LKAEALALLP CGLGMAFSQS HVMASRRHQH GRLIIEVDEY SSNPTQAFTF
     YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS RTDPIQMPYG DVLIHAGDFT
     ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN
     YENVQSLLTN CIYLQDSEVT VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD
     ILITHGPPLG FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV
     NASVCTVNYQ PVNPPIVIDL PTPRNS