MPR1_SCHPO
ID MPR1_SCHPO Reviewed; 295 AA.
AC O94321;
DT 14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Multistep phosphorelay regulator 1;
GN Name=mpr1; Synonyms=spy1; ORFNames=SPBC725.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF HIS-221, AND FUNCTION.
RX PubMed=10749922; DOI=10.1091/mbc.11.4.1169;
RA Nguyen A.N., Lee A., Place W., Shiozaki K.;
RT "Multistep phosphorelay proteins transmit oxidative stress signals to the
RT fission yeast stress-activated protein kinase.";
RL Mol. Biol. Cell 11:1169-1181(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Binds to the msc4 response regulator which is part of a
CC multistep phosphorelay system that transmits oxidative stress signals
CC to the spc1 MAPK cascade. {ECO:0000269|PubMed:10749922}.
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DR EMBL; CU329671; CAA22174.1; -; Genomic_DNA.
DR PIR; T40654; T40654.
DR RefSeq; NP_595482.1; NM_001021393.2.
DR AlphaFoldDB; O94321; -.
DR SMR; O94321; -.
DR BioGRID; 277692; 195.
DR IntAct; O94321; 4.
DR STRING; 4896.SPBC725.02.1; -.
DR iPTMnet; O94321; -.
DR MaxQB; O94321; -.
DR PaxDb; O94321; -.
DR PRIDE; O94321; -.
DR EnsemblFungi; SPBC725.02.1; SPBC725.02.1:pep; SPBC725.02.
DR GeneID; 2541178; -.
DR KEGG; spo:SPBC725.02; -.
DR PomBase; SPBC725.02; mpr1.
DR VEuPathDB; FungiDB:SPBC725.02; -.
DR eggNOG; KOG4747; Eukaryota.
DR HOGENOM; CLU_082193_0_0_1; -.
DR InParanoid; O94321; -.
DR OMA; DDDQHEF; -.
DR PRO; PR:O94321; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0009927; F:histidine phosphotransfer kinase activity; IDA:PomBase.
DR GO; GO:0043424; F:protein histidine kinase binding; IBA:GO_Central.
DR GO; GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IDA:PomBase.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IDA:PomBase.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR GO; GO:1900745; P:positive regulation of p38MAPK cascade; IMP:PomBase.
DR CDD; cd00088; HPT; 1.
DR Gene3D; 1.20.120.160; -; 1.
DR InterPro; IPR045871; AHP1-5/YPD1.
DR InterPro; IPR036641; HPT_dom_sf.
DR InterPro; IPR008207; Sig_transdc_His_kin_Hpt_dom.
DR PANTHER; PTHR28242; PTHR28242; 1.
DR Pfam; PF01627; Hpt; 1.
DR SMART; SM00073; HPT; 1.
DR SUPFAM; SSF47226; SSF47226; 1.
DR PROSITE; PS50894; HPT; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..295
FT /note="Multistep phosphorelay regulator 1"
FT /id="PRO_0000096558"
FT DOMAIN 182..284
FT /note="HPt"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00110"
FT REGION 89..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 221
FT /note="Phosphohistidine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00110"
FT MUTAGEN 221
FT /note="H->Q: Oxidative stress signaling to spc1 did not
FT occur."
FT /evidence="ECO:0000269|PubMed:10749922"
SQ SEQUENCE 295 AA; 32550 MW; 99207DA474E4F9E9 CRC64;
MSVYRDNMYM KYDRNFENRV ARRNGQARNA SLAKTLHDSG IAERARSPSG SAIPHAYRVM
NGSGANDTSL PLTSNPAYVA LTSRISSSKS ENNQQLAANE TAGAPEGTEE TVDISNSISD
DHANAKNLPA ASVKALVGAG VLSDELSVIA YDMSFEDELI QDKQLIDHSV FDQLLEMDDD
DEHEFSKSIV WNYFEQAETT IADLQKALEA KDLKKLSSLG HFLKGSSAVL GLTKMRKVCE
RIQNYGSLRS RDGVMKLPSE EIALDLISKS LSVVNDFYKD ARAYLLDFYE KNSST
