MPRAB_DANRE
ID MPRAB_DANRE Reviewed; 354 AA.
AC Q801G2;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Membrane progestin receptor alpha-B;
DE Short=mPR alpha;
DE AltName: Full=Progestin and adipoQ receptor family member VII, b;
GN Name=paqr7b; Synonyms=mpra, paqr7;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Ovary;
RX PubMed=12601167; DOI=10.1073/pnas.0436133100;
RA Zhu Y., Bond J., Thomas P.;
RT "Identification, classification, and partial characterization of genes in
RT humans and other vertebrates homologous to a fish membrane progestin
RT receptor.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003).
RN [2]
RP FUNCTION IN MEIOTIC MATURATION.
RX PubMed=12574519; DOI=10.1073/pnas.0336132100;
RA Zhu Y., Rice C.D., Pang Y., Pace M., Thomas P.;
RT "Cloning, expression, and characterization of a membrane progestin receptor
RT and evidence it is an intermediary in meiotic maturation of fish oocytes.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:2231-2236(2003).
RN [3]
RP DEVELOPMENTAL STAGE.
RX PubMed=15862564; DOI=10.1016/j.ygcen.2005.01.017;
RA Kazeto Y., Goto-Kazeto R., Trant J.M.;
RT "Membrane-bound progestin receptors in channel catfish and zebrafish ovary:
RT changes in gene expression associated with the reproductive cycles and
RT hormonal reagents.";
RL Gen. Comp. Endocrinol. 142:204-211(2005).
RN [4]
RP FUNCTION, STEROID BINDING, AND SUBCELLULAR LOCATION.
RX PubMed=16899559; DOI=10.1677/joe.1.06694;
RA Hanna R., Pang Y., Thomas P., Zhu Y.;
RT "Cell-surface expression, progestin binding, and rapid nongenomic signaling
RT of zebrafish membrane progestin receptors alpha and beta in transfected
RT cells.";
RL J. Endocrinol. 190:247-260(2006).
CC -!- FUNCTION: Steroid membrane receptor. Signals upon progestin binding,
CC resulting in rapid activation of MAPK and down-regulation of adenylyl
CC cyclase activity. Interacts with steroids with varying degrees of
CC affinity, showing specificity for activation by the maturation-inducing
CC steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Capable
CC of mediating progestin-induced oocyte maturation.
CC {ECO:0000269|PubMed:12574519, ECO:0000269|PubMed:16899559}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16899559};
CC Multi-pass membrane protein {ECO:0000269|PubMed:16899559}.
CC -!- DEVELOPMENTAL STAGE: In oocytes, expression is lowest in ovarian
CC follicles at stages I and II but gradually increases after the onset of
CC vitellogenic growth, peaking at vitellogenic stages (stage IIIB).
CC {ECO:0000269|PubMed:15862564}.
CC -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR EMBL; AY149121; AAN78115.1; -; mRNA.
DR RefSeq; NP_899188.1; NM_183345.1.
DR RefSeq; XP_005158387.1; XM_005158330.3.
DR AlphaFoldDB; Q801G2; -.
DR SMR; Q801G2; -.
DR STRING; 7955.ENSDARP00000043290; -.
DR PaxDb; Q801G2; -.
DR Ensembl; ENSDART00000043291; ENSDARP00000043290; ENSDARG00000034907.
DR Ensembl; ENSDART00000144069; ENSDARP00000112552; ENSDARG00000034907.
DR GeneID; 368256; -.
DR KEGG; dre:368256; -.
DR CTD; 368256; -.
DR ZFIN; ZDB-GENE-030728-2; paqr7b.
DR eggNOG; KOG0748; Eukaryota.
DR GeneTree; ENSGT00940000161438; -.
DR HOGENOM; CLU_052356_0_0_1; -.
DR InParanoid; Q801G2; -.
DR OMA; VHRIYSC; -.
DR OrthoDB; 1524940at2759; -.
DR PhylomeDB; Q801G2; -.
DR TreeFam; TF319738; -.
DR PRO; PR:Q801G2; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000034907; Expressed in brain and 10 other tissues.
DR ExpressionAtlas; Q801G2; baseline.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:ZFIN.
DR GO; GO:0003707; F:nuclear steroid receptor activity; IDA:UniProtKB.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0005496; F:steroid binding; IDA:ZFIN.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0001556; P:oocyte maturation; IMP:ZFIN.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IDA:UniProtKB.
DR GO; GO:0048545; P:response to steroid hormone; IDA:ZFIN.
DR GO; GO:0007165; P:signal transduction; IDA:ZFIN.
DR GO; GO:0043401; P:steroid hormone mediated signaling pathway; IDA:UniProtKB.
DR InterPro; IPR004254; AdipoR/HlyIII-related.
DR PANTHER; PTHR20855; PTHR20855; 1.
DR Pfam; PF03006; HlyIII; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Developmental protein; Differentiation; Lipid-binding;
KW Membrane; Oogenesis; Receptor; Reference proteome; Steroid-binding;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..354
FT /note="Membrane progestin receptor alpha-B"
FT /id="PRO_0000218838"
FT TOPO_DOM 1..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..110
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 111..131
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 132..141
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 163..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..244
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 266..277
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 299..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 319..339
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 340..354
FT /note="Extracellular"
FT /evidence="ECO:0000255"
SQ SEQUENCE 354 AA; 41383 MW; 1A52DBF5EDD31690 CRC64;
MATVVMEQIG RLFINAQQLR QIPRFLESAF PKLPCTVMVS DVPWVFRESH IITGYRPPDQ
NWRYYFLTLF QRHNESVNVW THLLASLIIL VKFQELSETV DFLRDPHAQP MFILLLAAFT
YLGCSALAHL LSAKSEISHY TFYFLDYVGV AVYQYGSALA HFYYVVEEEW HAQVRTFFLP
ASAFLAWLSC TGCCYGKYAS PKLPKFVHKL FQVVPSGLAY CLDISPVLHR IYRCYSSEHW
CADQAVVYHC YQVLFFLISA YFFSYPHPER WFPGRCDFIG QGHQIFHVFL VLCTLVQIEA
VRLDYTERRR LYEHLHGDLA HDAVALFIFT ACCSALTAFY VRKRVKTYLE EKQE
