ID   MPRA_ECO57              Reviewed;         176 AA.
AC   P0ACS1; P24201; P77027;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Transcriptional repressor MprA;
DE   AltName: Full=Protein EmrR;
GN   Name=mprA; Synonyms=emrR; OrderedLocusNames=Z3985, ECs3546;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Negative regulator of the multidrug operon emrAB.
CC       {ECO:0000250}.
CC   -!- INDUCTION: Autoregulated. {ECO:0000305}.
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DR   EMBL; AE005174; AAG57793.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB36969.1; -; Genomic_DNA.
DR   PIR; B91072; B91072.
DR   RefSeq; NP_311573.1; NC_002695.1.
DR   RefSeq; WP_000378442.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACS1; -.
DR   SMR; P0ACS1; -.
DR   STRING; 155864.EDL933_3850; -.
DR   EnsemblBacteria; AAG57793; AAG57793; Z3985.
DR   EnsemblBacteria; BAB36969; BAB36969; ECs_3546.
DR   GeneID; 66673447; -.
DR   GeneID; 914738; -.
DR   KEGG; ece:Z3985; -.
DR   KEGG; ecs:ECs_3546; -.
DR   PATRIC; fig|386585.9.peg.3701; -.
DR   eggNOG; COG1846; Bacteria.
DR   HOGENOM; CLU_083287_17_1_6; -.
DR   OMA; TEHAETY; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR000835; HTH_MarR-typ.
DR   InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF01047; MarR; 1.
DR   PRINTS; PR00598; HTHMARR.
DR   SMART; SM00347; HTH_MARR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS01117; HTH_MARR_1; 1.
DR   PROSITE; PS50995; HTH_MARR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..176
FT                   /note="Transcriptional repressor MprA"
FT                   /id="PRO_0000054374"
FT   DOMAIN          26..160
FT                   /note="HTH marR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ   SEQUENCE   176 AA;  20563 MW;  BF4D3E34DAD0718A CRC64;
     MDSSFTPIEQ MLKFRASRHE DFPYQEILLT RLCMHMQSKL LENRNKMLKA QGINETLFMA
     LITLESQENH SIQPSELSCA LGSSRTNATR IADELEKRGW IERRESDNDR RCLHLQLTEK
     GHEFLREVLP PQHNCLHQLW SALSTTEKDQ LEQITRKLLS RLDQMEQDGV VLEAMS