MPRA_ECOLI
ID MPRA_ECOLI Reviewed; 176 AA.
AC P0ACR9; P24201; P77027;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transcriptional repressor MprA;
DE AltName: Full=Protein EmrR;
GN Name=mprA; Synonyms=emrR; OrderedLocusNames=b2684, JW2659;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=K12;
RX PubMed=1840583; DOI=10.1128/jb.173.12.3924-3929.1991;
RA del Castillo I., Gonzalez-Pastor J.E., San Millan J.L., Moreno F.;
RT "Nucleotide sequence of the Escherichia coli regulatory gene mprA and
RT construction and characterization of mprA-deficient mutants.";
RL J. Bacteriol. 173:3924-3929(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=9205837; DOI=10.1093/dnares/4.2.91;
RA Yamamoto Y., Aiba H., Baba T., Hayashi K., Inada T., Isono K., Itoh T.,
RA Kimura S., Kitagawa M., Makino K., Miki T., Mitsuhashi N., Mizobuchi K.,
RA Mori H., Nakade S., Nakamura Y., Nashimoto H., Oshima T., Oyama S.,
RA Saito N., Sampei G., Satoh Y., Sivasundaram S., Tagami H., Takahashi H.,
RA Takeda J., Takemoto K., Uehara K., Wada C., Yamagata S., Horiuchi T.;
RT "Construction of a contiguous 874-kb sequence of the Escherichia coli-K12
RT genome corresponding to 50.0-68.8 min on the linkage map and analysis of
RT its sequence features.";
RL DNA Res. 4:91-113(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-176.
RX PubMed=1409590; DOI=10.1073/pnas.89.19.8938;
RA Lomovskaya O., Lewis K.;
RT "Emr, an Escherichia coli locus for multidrug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8938-8942(1992).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-5, AND FUNCTION.
RC STRAIN=K12;
RX PubMed=7730261; DOI=10.1128/jb.177.9.2328-2334.1995;
RA Lomovskaya O., Lewis K., Matin A.;
RT "EmrR is a negative regulator of the Escherichia coli multidrug resistance
RT pump EmrAB.";
RL J. Bacteriol. 177:2328-2334(1995).
CC -!- FUNCTION: Negative regulator of the multidrug operon emrAB.
CC {ECO:0000269|PubMed:7730261}.
CC -!- INDUCTION: Autoregulated.
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DR EMBL; X54151; CAA38090.1; -; Genomic_DNA.
DR EMBL; U00096; AAC75731.1; -; Genomic_DNA.
DR EMBL; AP009048; BAA16546.1; -; Genomic_DNA.
DR EMBL; M86657; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U19993; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; S14473; S14473.
DR RefSeq; NP_417169.1; NC_000913.3.
DR RefSeq; WP_000378442.1; NZ_STEB01000042.1.
DR AlphaFoldDB; P0ACR9; -.
DR SMR; P0ACR9; -.
DR BioGRID; 4262945; 13.
DR DIP; DIP-10248N; -.
DR IntAct; P0ACR9; 11.
DR STRING; 511145.b2684; -.
DR jPOST; P0ACR9; -.
DR PaxDb; P0ACR9; -.
DR PRIDE; P0ACR9; -.
DR EnsemblBacteria; AAC75731; AAC75731; b2684.
DR EnsemblBacteria; BAA16546; BAA16546; BAA16546.
DR GeneID; 66673447; -.
DR GeneID; 945282; -.
DR KEGG; ecj:JW2659; -.
DR KEGG; eco:b2684; -.
DR PATRIC; fig|1411691.4.peg.4056; -.
DR EchoBASE; EB0598; -.
DR eggNOG; COG1846; Bacteria.
DR HOGENOM; CLU_083287_17_1_6; -.
DR InParanoid; P0ACR9; -.
DR OMA; TEHAETY; -.
DR PhylomeDB; P0ACR9; -.
DR BioCyc; EcoCyc:EG10603-MON; -.
DR PHI-base; PHI:5407; -.
DR PHI-base; PHI:7646; -.
DR PRO; PR:P0ACR9; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR GO; GO:0046677; P:response to antibiotic; IMP:EcoCyc.
DR GO; GO:0006351; P:transcription, DNA-templated; IDA:EcoCyc.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000835; HTH_MarR-typ.
DR InterPro; IPR023187; Tscrpt_reg_MarR-type_CS.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF01047; MarR; 1.
DR PRINTS; PR00598; HTHMARR.
DR SMART; SM00347; HTH_MARR; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS01117; HTH_MARR_1; 1.
DR PROSITE; PS50995; HTH_MARR_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..176
FT /note="Transcriptional repressor MprA"
FT /id="PRO_0000054373"
FT DOMAIN 26..160
FT /note="HTH marR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00345"
SQ SEQUENCE 176 AA; 20563 MW; BF4D3E34DAD0718A CRC64;
MDSSFTPIEQ MLKFRASRHE DFPYQEILLT RLCMHMQSKL LENRNKMLKA QGINETLFMA
LITLESQENH SIQPSELSCA LGSSRTNATR IADELEKRGW IERRESDNDR RCLHLQLTEK
GHEFLREVLP PQHNCLHQLW SALSTTEKDQ LEQITRKLLS RLDQMEQDGV VLEAMS
