ID   MPRA_MYCLE              Reviewed;         228 AA.
AC   Q9CD68; Q9Z5G8;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 119.
DE   RecName: Full=Response regulator MprA;
DE   AltName: Full=Mycobacterial persistence regulator A;
GN   Name=mprA; OrderedLocusNames=ML0174; ORFNames=MLCB373.26;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Member of the two-component regulatory system MprB/MprA which
CC       contributes to maintaining a balance among several systems involved in
CC       stress resistance and is required for establishment and maintenance of
CC       persistent infection in the host. Functions as a transcriptional
CC       regulator that recognizes a 19-bp nucleotide motif comprizing two
CC       loosely conserved 8-bp direct DNA-binding motif repeats separated by a
CC       3-bp spacer region (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated and dephosphorylated by MprB. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB36688.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL035500; CAB36688.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL583917; CAC29682.1; -; Genomic_DNA.
DR   PIR; F86930; F86930.
DR   PIR; T45446; T45446.
DR   RefSeq; NP_301250.1; NC_002677.1.
DR   RefSeq; WP_010907575.1; NC_002677.1.
DR   AlphaFoldDB; Q9CD68; -.
DR   SMR; Q9CD68; -.
DR   STRING; 272631.ML0174; -.
DR   EnsemblBacteria; CAC29682; CAC29682; CAC29682.
DR   KEGG; mle:ML0174; -.
DR   PATRIC; fig|272631.5.peg.279; -.
DR   Leproma; ML0174; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_1_11; -.
DR   OMA; NYEFFGD; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Phosphoprotein; Reference proteome;
KW   Stress response; Transcription; Transcription regulation;
KW   Two-component regulatory system; Virulence.
FT   CHAIN           1..228
FT                   /note="Response regulator MprA"
FT                   /id="PRO_0000308421"
FT   DOMAIN          2..116
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        127..225
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         46
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   228 AA;  25599 MW;  53DE026D65DEC675 CRC64;
     MRILAVDDDR AVRESLRRSL SFNGYSVELA NDGVEALEMV ARDRPDALVL DVMMPRLDGL
     EVCRQLRSTG DDLPILVLTA RDSVSERVAG LDAGADDYLP KPFALEELLA RIRALLRRTK
     PDDAAESVAM SFSDLTLDPV TREVARGQRW ISLTRTEFAL LEMLIANPRR VLTRSRILEE
     VWGFDFPTSG NALEVYVGYL RRKTEADGES RLIHTVRGVG YVLRETPP