ID   MPRB_PIG                Reviewed;         354 AA.
AC   Q865K9;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Membrane progestin receptor beta;
DE            Short=mPR beta;
DE   AltName: Full=Progestin and adipoQ receptor family member VIII;
GN   Name=PAQR8; Synonyms=MPRB;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Small intestine;
RX   PubMed=12601167; DOI=10.1073/pnas.0436133100;
RA   Zhu Y., Bond J., Thomas P.;
RT   "Identification, classification, and partial characterization of genes in
RT   humans and other vertebrates homologous to a fish membrane progestin
RT   receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003).
CC   -!- FUNCTION: Steroid membrane receptor. Binds progesterone. May be
CC       involved in oocyte maturation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
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DR   EMBL; AF313615; AAO47228.1; -; mRNA.
DR   RefSeq; NP_998905.1; NM_213740.1.
DR   RefSeq; XP_005666525.1; XM_005666468.2.
DR   AlphaFoldDB; Q865K9; -.
DR   SMR; Q865K9; -.
DR   STRING; 9823.ENSSSCP00000001907; -.
DR   PaxDb; Q865K9; -.
DR   PRIDE; Q865K9; -.
DR   Ensembl; ENSSSCT00000001956; ENSSSCP00000001907; ENSSSCG00000001750.
DR   Ensembl; ENSSSCT00000081499; ENSSSCP00000071590; ENSSSCG00000001750.
DR   Ensembl; ENSSSCT00015021202; ENSSSCP00015008333; ENSSSCG00015015873.
DR   Ensembl; ENSSSCT00015021221; ENSSSCP00015008341; ENSSSCG00015015873.
DR   Ensembl; ENSSSCT00025065790; ENSSSCP00025028073; ENSSSCG00025048338.
DR   Ensembl; ENSSSCT00025065853; ENSSSCP00025028105; ENSSSCG00025048338.
DR   Ensembl; ENSSSCT00030045778; ENSSSCP00030020619; ENSSSCG00030033056.
DR   Ensembl; ENSSSCT00030045800; ENSSSCP00030020628; ENSSSCG00030033056.
DR   Ensembl; ENSSSCT00035086430; ENSSSCP00035036004; ENSSSCG00035064220.
DR   Ensembl; ENSSSCT00035086434; ENSSSCP00035036006; ENSSSCG00035064220.
DR   Ensembl; ENSSSCT00040020364; ENSSSCP00040008529; ENSSSCG00040015133.
DR   Ensembl; ENSSSCT00040020371; ENSSSCP00040008532; ENSSSCG00040015133.
DR   Ensembl; ENSSSCT00045005435; ENSSSCP00045003632; ENSSSCG00045003327.
DR   Ensembl; ENSSSCT00045005442; ENSSSCP00045003638; ENSSSCG00045003327.
DR   Ensembl; ENSSSCT00050002338; ENSSSCP00050000714; ENSSSCG00050001839.
DR   Ensembl; ENSSSCT00050002350; ENSSSCP00050000719; ENSSSCG00050001839.
DR   Ensembl; ENSSSCT00055026468; ENSSSCP00055021032; ENSSSCG00055013439.
DR   Ensembl; ENSSSCT00055026492; ENSSSCP00055021053; ENSSSCG00055013439.
DR   Ensembl; ENSSSCT00060064119; ENSSSCP00060027497; ENSSSCG00060047213.
DR   Ensembl; ENSSSCT00060064122; ENSSSCP00060027498; ENSSSCG00060047213.
DR   Ensembl; ENSSSCT00065105961; ENSSSCP00065047075; ENSSSCG00065076681.
DR   Ensembl; ENSSSCT00065105964; ENSSSCP00065047076; ENSSSCG00065076681.
DR   Ensembl; ENSSSCT00070017875; ENSSSCP00070014833; ENSSSCG00070009207.
DR   GeneID; 396559; -.
DR   KEGG; ssc:396559; -.
DR   CTD; 85315; -.
DR   VGNC; VGNC:91178; PAQR8.
DR   eggNOG; KOG0748; Eukaryota.
DR   GeneTree; ENSGT00940000159860; -.
DR   HOGENOM; CLU_052356_0_0_1; -.
DR   InParanoid; Q865K9; -.
DR   OMA; QYGCSLG; -.
DR   OrthoDB; 1524940at2759; -.
DR   TreeFam; TF319738; -.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Proteomes; UP000314985; Chromosome 7.
DR   Bgee; ENSSSCG00000001750; Expressed in hypothalamus and 43 other tissues.
DR   ExpressionAtlas; Q865K9; baseline and differential.
DR   Genevisible; Q865K9; SS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0003707; F:nuclear steroid receptor activity; IBA:GO_Central.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0005496; F:steroid binding; IBA:GO_Central.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0048545; P:response to steroid hormone; IBA:GO_Central.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Differentiation; Lipid-binding;
KW   Membrane; Oogenesis; Receptor; Reference proteome; Steroid-binding;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..354
FT                   /note="Membrane progestin receptor beta"
FT                   /id="PRO_0000218842"
FT   TOPO_DOM        1..75
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..111
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        133..174
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        196..213
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        214..234
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        235..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..283
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        284..304
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        305..319
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        341..354
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   354 AA;  40581 MW;  C7B72F0301E46D5B CRC64;
     MTTAILQRLS TLSVSGQHLR RLPKILEDGL PKMPGTVPET DVPQLFREPY IRAGYRPIGH
     EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFVETE GLPWTSAHTL PLLLYVLSSI
     TYLTFSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL VHFFYASDQA WYERFWLFFL
     PAAAFCGWLS CTGCCYAKYR YRRPYPVMRK VCQVVPAGLA FILDISPVAH RVALCHLSGC
     QEQAAWYHTL QIVFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS ICTLSQLEAI
     LLDYKGRQEI FLHRHSPLSI YAACLSFFFL VACSGATAAL LREKIKARLS KKDS