ID   MPRGB_DANRE             Reviewed;         347 AA.
AC   Q6DC77;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Membrane progestin receptor gamma-B;
DE            Short=mPR gamma-B;
DE   AltName: Full=Progestin and adipoQ receptor family member V-B;
GN   Name=paqr5b {ECO:0000312|ZFIN:ZDB-GENE-040801-92}; ORFNames=zgc:101065;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH78202.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH78202.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Steroid membrane receptor. Binds progesterone. May be
CC       involved in oocyte maturation (By similarity).
CC       {ECO:0000250|UniProtKB:Q9NXK6}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q86WK9,
CC       ECO:0000255}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q86WK9, ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000255}.
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DR   EMBL; BC078202; AAH78202.1; -; mRNA.
DR   RefSeq; NP_001003573.1; NM_001003573.2.
DR   AlphaFoldDB; Q6DC77; -.
DR   STRING; 7955.ENSDARP00000069075; -.
DR   PaxDb; Q6DC77; -.
DR   Ensembl; ENSDART00000074587; ENSDARP00000069075; ENSDARG00000052688.
DR   GeneID; 100007661; -.
DR   KEGG; dre:100007661; -.
DR   CTD; 100007661; -.
DR   ZFIN; ZDB-GENE-040801-92; paqr5b.
DR   eggNOG; KOG0748; Eukaryota.
DR   GeneTree; ENSGT00940000158844; -.
DR   InParanoid; Q6DC77; -.
DR   OrthoDB; 1524940at2759; -.
DR   PhylomeDB; Q6DC77; -.
DR   TreeFam; TF319738; -.
DR   PRO; PR:Q6DC77; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000052688; Expressed in swim bladder and 8 other tissues.
DR   ExpressionAtlas; Q6DC77; differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR   GO; GO:0005496; F:steroid binding; IEA:UniProtKB-KW.
DR   GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR004254; AdipoR/HlyIII-related.
DR   PANTHER; PTHR20855; PTHR20855; 1.
DR   Pfam; PF03006; HlyIII; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Lipid-binding; Membrane; Oogenesis;
KW   Receptor; Reference proteome; Steroid-binding; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..347
FT                   /note="Membrane progestin receptor gamma-B"
FT                   /id="PRO_0000273242"
FT   TOPO_DOM        1..52
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        53..73
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        74..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..138
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        139..159
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        160..201
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        223..235
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        336..347
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   347 AA;  39519 MW;  68127137C85AD4D7 CRC64;
     MLSLIKLQRV FNVHQVPKAF HEDGIISGYR HPRSSATECV WSLFQLTNET LNVWTHFLPT
     WYFLWKLMTV LLMEDVWNEA YTWPLLVFLF SCCVYPLASS CAHTFSSMST RARHICYFFD
     YGALSFYSLG SAISYSAYVF PDAWLSSSFH AYYISVAVFN TVLSTSLACY SRLGLPLLHY
     SHDIVERFSE RQCPRMSKVL RILAFAYPYL FDNIPLFYRL FVCVGEGCTD NEANSVHVQH
     TLLAFLTSFL FATHLPERLA PGRFDYIGHS HQLFHVCAII GTHFQMKAIE MDMGLRRSQL
     LASAPAISFN NTIGAALLCV SVSLGIICVY SLPLLYSSNP KNTANKE