ID   MPRR1_STRCH             Reviewed;         316 AA.
AC   P43160;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Small neutral protease regulatory protein;
GN   Name=mprR;
OS   Streptomyces coelicolor.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=1902;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DSM 3030 / Mueller;
RX   PubMed=1406267; DOI=10.1111/j.1365-2958.1992.tb01402.x;
RA   Dammann T., Wohlleben W.;
RT   "A metalloprotease gene from Streptomyces coelicolor 'Muller' and its
RT   transcriptional activator, a member of the LysR family.";
RL   Mol. Microbiol. 6:2267-2278(1992).
CC   -!- FUNCTION: Transcriptional trans-activator of the gene (mprA) for the
CC       small neutral protease.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; Z11929; CAA77986.1; -; Genomic_DNA.
DR   PIR; S25188; S25188.
DR   AlphaFoldDB; P43160; -.
DR   SMR; P43160; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..316
FT                   /note="Small neutral protease regulatory protein"
FT                   /id="PRO_0000105683"
FT   DOMAIN          1..56
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        16..35
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   316 AA;  33888 MW;  9B39A580A2C8CC44 CRC64;
     MRHLRALCAI ADTGSVRRAA RELGVSQPAL TTQLRRIEQS LGAELFHRGR DGCRPTLLGR
     TVLSRARTVV DSMAVLVEEA RAEAAALGRP GPRLRVGSTA SRIVGDWLRR LRGRMPETDI
     TLQVDVSATV LLRCCAPAAL DLAFVHEVEG SPLRVPDGLV QHTLLEREPQ FISLAPDHPA
     AARPVVDLAD LAQDRWMVDP SVDGEWDGVR RVLAAAGIDP PVLHGDYLTT ASLVALGEAV
     APCQPTSGPR DDMVIRPLRD DPLAVRLLLV TPPRCPAAGP AYEELTAAYA AAALRAGPYR
     EWLEGAPERP GALLGG