ID   MPRR2_STRCO             Reviewed;         328 AA.
AC   Q9L127;
DT   02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Small neutral protease regulatory protein;
GN   Name=mprR; Synonyms=mprR2; OrderedLocusNames=SCO7433; ORFNames=SC6D11.29;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Transcriptional trans-activator of the gene (mprA) for the
CC       small neutral protease.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AL939131; CAB76352.1; -; Genomic_DNA.
DR   RefSeq; NP_631482.1; NC_003888.3.
DR   RefSeq; WP_011031660.1; NZ_VNID01000005.1.
DR   AlphaFoldDB; Q9L127; -.
DR   SMR; Q9L127; -.
DR   STRING; 100226.SCO7433; -.
DR   GeneID; 1102871; -.
DR   KEGG; sco:SCO7433; -.
DR   PATRIC; fig|100226.15.peg.7543; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_4_11; -.
DR   OMA; HEVEGCP; -.
DR   PhylomeDB; Q9L127; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0032993; C:protein-DNA complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..328
FT                   /note="Small neutral protease regulatory protein"
FT                   /id="PRO_0000105684"
FT   DOMAIN          1..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   328 AA;  35885 MW;  2BA97730AE4FA16B CRC64;
     MELEVRHLRA LCAIADAGSL HRAARRLGVA QPTLSTQLTR IEQALGGPLF TRERTGCRPT
     PLGRTVLGRA RPLLTDMNTL VREARAAAAG GDSRLRVGST ASRALAGWLR RLRRPGLEPT
     LQMDVSANAL LRRVTDGQLD VAFVHEVEGC ALHIPEDLRL RVLVEREPQF VMLPADHPAA
     ARPVVRLADL ADDRWMVDPT VDGEWDGVHR MLRAVGLNPR VLHGDYHTAA SLVATGEVVT
     VCQPSSQSRP DTAVRRLYGD PLGVRLLLAA RTRAELDAVF PALEDAYWEA ARQSTAYREW
     LEGGGIRTLP RCPVAATGGG RVEFVRAR