ID   MPRR_STRLI              Reviewed;         344 AA.
AC   P43161;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Small neutral protease regulatory protein;
GN   Name=mprR; Synonyms=snpR;
OS   Streptomyces lividans.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1916;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=66 / 1326;
RX   PubMed=1464066; DOI=10.1139/m92-148;
RA   Butler M.J., Davey C.C., Krygsman P., Walczyk E., Malek L.T.;
RT   "Cloning of genetic loci involved in endoprotease activity in Streptomyces
RT   lividans 66: a novel neutral protease gene with an adjacent divergent
RT   putative regulatory gene.";
RL   Can. J. Microbiol. 38:912-920(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-305.
RC   STRAIN=TK24;
RX   PubMed=1547948; DOI=10.1016/0378-1119(92)90613-t;
RA   Lichenstein H.S., Busse L.A., Smith G.A., Narhi L.O., McGinley M.O.,
RA   Rohde M.F., Katzowitz J.L., Zukowski M.M.;
RT   "Cloning and characterization of a gene encoding extracellular
RT   metalloprotease from Streptomyces lividans.";
RL   Gene 111:125-130(1992).
CC   -!- FUNCTION: Transcriptional activator of the gene (snpA) for the small
CC       neutral protease.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA26804.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; M81703; AAA26739.1; -; Genomic_DNA.
DR   EMBL; M89476; AAA26804.1; ALT_INIT; Genomic_DNA.
DR   PIR; A48990; A48990.
DR   PIR; JH0572; JH0572.
DR   AlphaFoldDB; P43161; -.
DR   SMR; P43161; -.
DR   PRIDE; P43161; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..344
FT                   /note="Small neutral protease regulatory protein"
FT                   /id="PRO_0000105685"
FT   DOMAIN          1..60
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        20..39
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   REGION          322..344
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        270
FT                   /note="G -> AR (in Ref. 2; AAA26804)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   344 AA;  37416 MW;  485C82C813B52312 CRC64;
     MELEVRHLRA LCAIADAGSL HRAARRLGVA QPTLSTQLTR IEQALGGPLF TRERTGCRPT
     PLGRTVLGRA RPLLTDMNTL VREARAAAAG GDSRLRVGST ASRALAGWLR RLRRPGLEPT
     LQMDVSANAL LRRVTDGQLD VAFVHEVEGC ALHIPEDLRL RVLVEREPQF VMLPADHPAA
     ARPVVRLADL ADDRWMVDPT VDGEWDGVHR MLRAVGLNPR VLHGDYHTAA SLVATGEVVT
     VCQPSSQSRP DTAVRRLYGD PLGVRLLLAG TRAELDAVFP ALEDAYWEAA RQSTAYREWL
     EGGGIRTLPR CPVAATGGGR VSCGRAEGSR SRRPRDVAPP RPIG