ID   MPS2_CANGA              Reviewed;         356 AA.
AC   Q6FS52;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Monopolar spindle protein 2;
GN   Name=MPS2; OrderedLocusNames=CAGL0H03421g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) required for
CC       insertion of the nascent SPB into the nuclear envelope and for the
CC       proper execution of spindle pole body (SPB) duplication. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, spindle pole body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MPS2 family. {ECO:0000305}.
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DR   EMBL; CR380954; CAG59875.1; -; Genomic_DNA.
DR   RefSeq; XP_446942.1; XM_446942.1.
DR   AlphaFoldDB; Q6FS52; -.
DR   SMR; Q6FS52; -.
DR   STRING; 5478.XP_446942.1; -.
DR   PRIDE; Q6FS52; -.
DR   EnsemblFungi; CAG59875; CAG59875; CAGL0H03421g.
DR   GeneID; 2888827; -.
DR   KEGG; cgr:CAGL0H03421g; -.
DR   CGD; CAL0131886; CAGL0H03421g.
DR   VEuPathDB; FungiDB:CAGL0H03421g; -.
DR   eggNOG; ENOG502RYE7; Eukaryota.
DR   HOGENOM; CLU_069890_0_0_1; -.
DR   InParanoid; Q6FS52; -.
DR   OMA; FIYAKDF; -.
DR   Proteomes; UP000002428; Chromosome H.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0071988; P:protein localization to spindle pole body; IEA:InterPro.
DR   GO; GO:0030474; P:spindle pole body duplication; IEA:InterPro.
DR   InterPro; IPR031433; Mps2.
DR   Pfam; PF17060; MPS2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..356
FT                   /note="Monopolar spindle protein 2"
FT                   /id="PRO_0000409156"
FT   TRANSMEM        285..305
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          165..264
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   356 AA;  41680 MW;  2D3619F8FA37EFB6 CRC64;
     MSEVDVPELL FERVWLQVDR DRDGFIYAKQ MPSFITQCEQ VIKDTVNTNK TDFHMTRFKN
     RLKLPLLPKL HMDLIDAFAK ETPYYKIYKE SFSDMLNKLT GNNFSTVINK IFEDCDGFPA
     SFISALEVKA DVKSSPRSKA DSLGSPIKVD LLRNLKPQEE PETPRRINRK YKSLELQLES
     MKRELEDKEK TIMNNERNLT ELRSTISKLK EKYDLLSEEY EQRHIHGGNN GTAIKHDVVI
     GELKSRLQEQ NRLIRILQEQ IQFDPQLKRE TRVHDNKSKN NTFNGAIAYV IPFLLFIFVI
     RSLITKEDIG DATMALPWWE RNNLASRLAW YFRDVFSNDS AKFLESDAYD KVFGIH