ID   MPS2_KLULA              Reviewed;         322 AA.
AC   Q6CS73;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Monopolar spindle protein 2;
GN   Name=MPS2; OrderedLocusNames=KLLA0D03366g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) required for
CC       insertion of the nascent SPB into the nuclear envelope and for the
CC       proper execution of spindle pole body (SPB) duplication. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, spindle pole body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MPS2 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00312.1; -; Genomic_DNA.
DR   RefSeq; XP_453216.1; XM_453216.1.
DR   AlphaFoldDB; Q6CS73; -.
DR   SMR; Q6CS73; -.
DR   STRING; 28985.XP_453216.1; -.
DR   EnsemblFungi; CAH00312; CAH00312; KLLA0_D03366g.
DR   GeneID; 2893076; -.
DR   KEGG; kla:KLLA0_D03366g; -.
DR   eggNOG; ENOG502RYE7; Eukaryota.
DR   HOGENOM; CLU_069890_0_0_1; -.
DR   InParanoid; Q6CS73; -.
DR   OMA; FIYAKDF; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0071988; P:protein localization to spindle pole body; IEA:InterPro.
DR   GO; GO:0030474; P:spindle pole body duplication; IEA:InterPro.
DR   InterPro; IPR031433; Mps2.
DR   Pfam; PF17060; MPS2; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..322
FT                   /note="Monopolar spindle protein 2"
FT                   /id="PRO_0000409157"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          147..217
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   322 AA;  37629 MW;  81BAA2338A589207 CRC64;
     MTKQISKSTQ YKPSKSTLVS AKLFSMNRTE STRLLDRAWS VLESGSDGYV YAKDIPEIIS
     FIDRELPSKL TTQSNDKVIE SWVNNDPMKT LSKEQFLEAF SMLVGTSFDT AVQIAMQSDI
     LTPTRRGASL FGSYRRSSND LEQVLPAEQI KALKRELQEW KDKYTFLEHE FQFFLSQEKK
     NPEVIDNTKH EFIISELNRK LREQDEAIED LKSQLDYGLV PELKDKTNWI KALQRKAYNY
     LLPKILICLL LLLLYYCLAA KILFTKSSST DDVPSFIRQQ SWWERNKILS RIQWYFKDRI
     ENNVVRNSSE VIQNYNSVFG IH