ID   MPS2_LACTC              Reviewed;         386 AA.
AC   C5E2E7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Monopolar spindle protein 2;
GN   Name=MPS2; OrderedLocusNames=KLTH0H04312g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) required for
CC       insertion of the nascent SPB into the nuclear envelope and for the
CC       proper execution of spindle pole body (SPB) duplication. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, spindle pole body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MPS2 family. {ECO:0000305}.
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DR   EMBL; CU928180; CAR30208.1; -; Genomic_DNA.
DR   RefSeq; XP_002556070.1; XM_002556024.1.
DR   AlphaFoldDB; C5E2E7; -.
DR   SMR; C5E2E7; -.
DR   STRING; 559295.C5E2E7; -.
DR   EnsemblFungi; CAR30208; CAR30208; KLTH0H04312g.
DR   GeneID; 8294383; -.
DR   KEGG; lth:KLTH0H04312g; -.
DR   eggNOG; ENOG502RYE7; Eukaryota.
DR   HOGENOM; CLU_069890_0_0_1; -.
DR   InParanoid; C5E2E7; -.
DR   OMA; FIYAKDF; -.
DR   OrthoDB; 1039572at2759; -.
DR   Proteomes; UP000002036; Chromosome H.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0071988; P:protein localization to spindle pole body; IEA:InterPro.
DR   GO; GO:0030474; P:spindle pole body duplication; IEA:InterPro.
DR   InterPro; IPR031433; Mps2.
DR   Pfam; PF17060; MPS2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..386
FT                   /note="Monopolar spindle protein 2"
FT                   /id="PRO_0000409158"
FT   TRANSMEM        296..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   COILED          117..232
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   386 AA;  44080 MW;  3FF919CDD591D378 CRC64;
     MDTERHATLL LDLVWPEVDE KAQGFIYAKD FPLVVSRMEE ILNRGKLERD RAQLVSETGR
     EILRKFGSDQ EFFKVYKEDF RELFDGLVGT SFKSAVKSCA GDGVLDRLQD SQAVDGIQDE
     KTSSHALQEE VMRLREQVRV LSSKNDEKDR EITARDEIIA DLQGKDASPA GSPRSLQRMR
     TLQARVTSLE DELSFRDEVI REKDRELLNL TKRVGEFKDK YQFLEREFQF YKGHREQKSP
     DSIKEATRHE FIISELRRKI TEQSEIIGQM RMQVEAKPGA LHPQGIGSTA GLPLNLPLRL
     VLRLIIGAIL AYLAFDIGIR SLKAVGGLFG SSSPATLTPK SELSWWEQNT LLSKLLWFFK
     DLFDTYNLDA GRDEVVSANY DKLFGV