MPS2_YEAS1
ID MPS2_YEAS1 Reviewed; 387 AA.
AC B3LHE1;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Monopolar spindle protein 2;
GN Name=MPS2; Synonyms=MMC1; ORFNames=SCRG_01074;
OS Saccharomyces cerevisiae (strain RM11-1a) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=285006;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RM11-1a;
RG The Broad Institute Genome Sequencing Platform;
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Cuomo C.,
RA Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M.,
RA Mauceli E.W., Brockman W., MacCallum I.A., Rounsley S., Young S.K.,
RA LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA O'Leary S., Kodira C.D., Zeng Q., Yandava C., Alvarado L., Pratt S.,
RA Kruglyak L.;
RT "Annotation of the Saccharomyces cerevisiae RM11-1a genome.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the spindle pole body (SPB) required for
CC insertion of the nascent SPB into the nuclear envelope and for the
CC proper execution of spindle pole body (SPB) duplication. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with BBP1, MPS3, and SPC24. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, spindle pole body {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MPS2 family. {ECO:0000305}.
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DR EMBL; CH408044; EDV10299.1; -; Genomic_DNA.
DR AlphaFoldDB; B3LHE1; -.
DR SMR; B3LHE1; -.
DR EnsemblFungi; EDV10299; EDV10299; SCRG_01074.
DR HOGENOM; CLU_069890_0_0_1; -.
DR Proteomes; UP000008335; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR GO; GO:0071988; P:protein localization to spindle pole body; IEA:InterPro.
DR GO; GO:0030474; P:spindle pole body duplication; IEA:InterPro.
DR InterPro; IPR031433; Mps2.
DR Pfam; PF17060; MPS2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Nucleus; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..387
FT /note="Monopolar spindle protein 2"
FT /id="PRO_0000409159"
FT TRANSMEM 311..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 216..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 157..269
FT /evidence="ECO:0000255"
FT COMPBIAS 216..234
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 387 AA; 44548 MW; 0BA11A86E6331A68 CRC64;
MSNGAFDAIF EYAWGQIDKP ISGDFIYGKD LPKLIEIIEN IFQKAQKSGS YELRLPLFSE
INKDLFRTFS NTKTFFKIHK EEFDDIFFNL VNHPLREILE NAFIGVDSIP SDFIVSMNLN
SPSKFLVENK SKNTEGAGIS TSRKKLTESP IKLLSRNNIG KALEVQVEEL KRELTAKQSL
LQENERQVSE LKIRLETYQE KYASIQQRFS DLQKARQVED NQNSSRTSDP GSPLVTGIDQ
KAILEEFRRR LQRQTDTISF LKDQIRRERG LNCSNDKVSH SKRKHATTDG DGTFKNFISA
VPSNIWVKAT IRIIVCFALL AGVLPYIRKY VYAHDTPSQN SRLQLSWWEN SGILSKIVWF
FEDQTDLETE YRSNANVDDA YSRVFGI
