ID   MPS2_ZYGRC              Reviewed;         343 AA.
AC   C5E006;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Monopolar spindle protein 2;
GN   Name=MPS2; OrderedLocusNames=ZYRO0G08712g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Component of the spindle pole body (SPB) required for
CC       insertion of the nascent SPB into the nuclear envelope and for the
CC       proper execution of spindle pole body (SPB) duplication. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, spindle pole body {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MPS2 family. {ECO:0000305}.
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DR   EMBL; CU928179; CAR29440.1; -; Genomic_DNA.
DR   RefSeq; XP_002498373.1; XM_002498328.1.
DR   AlphaFoldDB; C5E006; -.
DR   SMR; C5E006; -.
DR   STRING; 559307.C5E006; -.
DR   EnsemblFungi; CAR29440; CAR29440; ZYRO0G08712g.
DR   GeneID; 8206176; -.
DR   KEGG; zro:ZYRO0G08712g; -.
DR   HOGENOM; CLU_069890_0_0_1; -.
DR   InParanoid; C5E006; -.
DR   Proteomes; UP000008536; Chromosome G.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell.
DR   GO; GO:0071988; P:protein localization to spindle pole body; IEA:InterPro.
DR   GO; GO:0030474; P:spindle pole body duplication; IEA:InterPro.
DR   InterPro; IPR031433; Mps2.
DR   Pfam; PF17060; MPS2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Membrane; Nucleus;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..343
FT                   /note="Monopolar spindle protein 2"
FT                   /id="PRO_0000409169"
FT   TRANSMEM        264..284
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          102..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          127..243
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   343 AA;  39859 MW;  502EC0473EF7AE6F CRC64;
     MDFDKSSSSL VLDLAWNQVD KKNQDFIYAK DFPALIMSIE EILSRGQQTP LAFLSNTGKS
     VIDTFAREKE FFKIYRDEFK EIFHGLVGKT FKDTIEGTNV SRSVLDEQGQ EPDVSTTPTR
     QQRSSPRKVN RLLKNLETRV ASMKDELKFK DEILAEKDRE LIQLTRKLSD YKDKYEFVQR
     QFSFYKDHGE SPRRNSSESE QLNLEQNAST KHEFIISELK RKLQEQTLAI SNLKEQLQRG
     EGAGVLYTNY SKRYNPLHND GPMVLVLATL VFLTIILLIG SMIWVTGGKD DSNSFSQYSW
     WENNSLLSRI GWFFRDWSDT GVDYVNFEPS SDAYERIMGI RRI