ID   MPT51_MYCBO             Reviewed;         299 AA.
AC   P0A4V7; A0A1R3Y5B3; O33176; Q48923; X2BPV6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=MPT51/MPB51 antigen;
DE   Flags: Precursor;
GN   Name=mpt51; Synonyms=fbpD, mpb51; OrderedLocusNames=BQ2027_MB3833C;
OS   Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=233413;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=BCG / Tokyo;
RX   PubMed=7725062; DOI=10.1111/j.1365-3083.1995.tb03589.x;
RA   Ohara N., Kitaura H., Hotokezaka H., Nishiyama T., Wada N., Matsumoto S.,
RA   Matsuo T., Naito M., Yamada T.;
RT   "Characterization of the gene encoding the MPB51, one of the major secreted
RT   protein antigens of Mycobacterium bovis BCG, and identification of the
RT   secreted protein closely related to the fibronectin binding 85 complex.";
RL   Scand. J. Immunol. 41:433-442(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA   Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA   Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA   Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA   Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT   "The complete genome sequence of Mycobacterium bovis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-935 / AF2122/97;
RX   PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA   Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA   Robbe-Austerman S., Gordon S.V.;
RT   "Updated reference genome sequence and annotation of Mycobacterium bovis
RT   AF2122/97.";
RL   Genome Announc. 5:E00157-E00157(2017).
CC   -!- FUNCTION: May have a role in host tissue attachment, whereby ligands
CC       may include the serum protein fibronectin and small sugars.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mycobacterial A85 antigen family.
CC       {ECO:0000305}.
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DR   EMBL; D26486; BAA05497.1; -; Genomic_DNA.
DR   EMBL; LT708304; SIU02462.1; -; Genomic_DNA.
DR   RefSeq; NP_857470.1; NC_002945.3.
DR   RefSeq; WP_003420783.1; NC_002945.4.
DR   AlphaFoldDB; P0A4V7; -.
DR   SMR; P0A4V7; -.
DR   ESTHER; myctu-mpt51; A85-Mycolyl-transferase.
DR   EnsemblBacteria; SIU02462; SIU02462; BQ2027_MB3833C.
DR   GeneID; 45427804; -.
DR   PATRIC; fig|233413.5.peg.4191; -.
DR   OMA; VDGNGMW; -.
DR   Proteomes; UP000001419; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000801; Esterase-like.
DR   Pfam; PF00756; Esterase; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Secreted; Signal; Transferase.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..299
FT                   /note="MPT51/MPB51 antigen"
FT                   /id="PRO_0000000228"
SQ   SEQUENCE   299 AA;  31089 MW;  4E2E38F87AEDD73E CRC64;
     MKGRSALLRA LWIAALSFGL GGVAVAAEPT AKAAPYENLM VPSPSMGRDI PVAFLAGGPH
     AVYLLDAFNA GPDVSNWVTA GNAMNTLAGK GISVVAPAGG AYSMYTNWEQ DGSKQWDTFL
     SAELPDWLAA NRGLAPGGHA AVGAAQGGYG AMALAAFHPD RFGFAGSMSG FLYPSNTTTN
     GAIAAGMQQF GGVDTNGMWG APQLGRWKWH DPWVHASLLA QNNTRVWVWS PTNPGASDPA
     AMIGQAAEAM GNSRMFYNQY RSVGGHNGHF DFPASGDNGW GSWAPQLGAM SGDIVGAIR