ID   MPT51_MYCLE             Reviewed;         301 AA.
AC   Q05868; Q50207;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   27-APR-2001, sequence version 2.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=MPT51 antigen;
DE   Flags: Precursor;
GN   Name=mpt51; OrderedLocusNames=ML0098;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Thai53;
RA   Yin Y.;
RT   "Studies of MPT51 like protein of Mycobacterium leprae.";
RL   Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220.
RX   PubMed=8359887; DOI=10.1128/iai.61.9.3642-3647.1993;
RA   Rinke de Wit T.F., Bekelie S., Osland A., Wieles B., Janson A.A.M.,
RA   Thole J.E.R.;
RT   "The Mycobacterium leprae antigen 85 complex gene family: identification of
RT   the genes for the 85A, 85C, and related MPT51 proteins.";
RL   Infect. Immun. 61:3642-3647(1993).
CC   -!- FUNCTION: May have a role in host tissue attachment, whereby ligands
CC       may include the serum protein fibronectin and small sugars.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the mycobacterial A85 antigen family.
CC       {ECO:0000305}.
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DR   EMBL; D50488; BAA09079.1; -; Genomic_DNA.
DR   EMBL; AL583917; CAC29606.1; -; Genomic_DNA.
DR   EMBL; Z21949; CAA79947.1; -; Genomic_DNA.
DR   PIR; B86921; B86921.
DR   PIR; S32111; S32111.
DR   RefSeq; NP_301196.1; NC_002677.1.
DR   RefSeq; WP_010907521.1; NC_002677.1.
DR   AlphaFoldDB; Q05868; -.
DR   SMR; Q05868; -.
DR   STRING; 272631.ML0098; -.
DR   ESTHER; mycle-mpt5; A85-Mycolyl-transferase.
DR   EnsemblBacteria; CAC29606; CAC29606; CAC29606.
DR   KEGG; mle:ML0098; -.
DR   PATRIC; fig|272631.5.peg.152; -.
DR   Leproma; ML0098; -.
DR   eggNOG; COG0627; Bacteria.
DR   HOGENOM; CLU_026624_3_1_11; -.
DR   OMA; VDGNGMW; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000801; Esterase-like.
DR   Pfam; PF00756; Esterase; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Reference proteome; Secreted; Signal; Transferase.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..301
FT                   /note="MPT51 antigen"
FT                   /id="PRO_0000000229"
FT   CONFLICT        41
FT                   /note="S -> F (in Ref. 1; BAA09079)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        286..301
FT                   /note="APQLAAMSGDIVGAIR -> GAAVGCYVGRYRRRHSLGRNQWHGRCCGDEPV
FT                   SCMGRARMVSGEHRHRTPYVHRNLPRDLPILLAGDPEWSRKCHVSATESSPGRLPCRWR
FT                   PSWRWPLWLW (in Ref. 1; BAA09079)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   301 AA;  31191 MW;  3E6866C805BFAB28 CRC64;
     MRGLSAVVRV LCVAALAVGV FAAAVLLAGT AGNAKAAGYE SLMVPSNAMG RDIPVAFMAG
     GPHAVYLLDA FNAALDVSNW VTAGNAMTTL GGRGISVVAP AGGAYSMYTN WENDGSKQWD
     TFLSSELPDW LATKRGLAPD GHAAVGASQG GYAALALAAF HPDRFGFAGS LSGFVYPSST
     NYNGAILAGL QQFGGIDGNG MWGAPQLGRW KWHDPYVHAS LLAQNNTRVW VYSPMTMGGD
     IDAMIGQAVA SMGSSREFYQ QYRSVGGHNG HFDFSGGGDN GWGAWAPQLA AMSGDIVGAI
     R