MPT51_MYCTO
ID MPT51_MYCTO Reviewed; 299 AA.
AC P9WQN6; L0TFA7; O33176; P0A4V6; Q48923;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=MPT51/MPB51 antigen;
DE Flags: Precursor;
GN Name=mpt51; Synonyms=fbpC1, fbpD, mpb51; OrderedLocusNames=MT3910;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: May have a role in host tissue attachment, whereby ligands
CC may include the serum protein fibronectin and small sugars.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the mycobacterial A85 antigen family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK48276.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE000516; AAK48276.1; ALT_INIT; Genomic_DNA.
DR PIR; G70887; G70887.
DR RefSeq; WP_003420783.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WQN6; -.
DR SMR; P9WQN6; -.
DR ESTHER; myctu-mpt51; A85-Mycolyl-transferase.
DR EnsemblBacteria; AAK48276; AAK48276; MT3910.
DR GeneID; 45427804; -.
DR KEGG; mtc:MT3910; -.
DR PATRIC; fig|83331.31.peg.4207; -.
DR HOGENOM; CLU_026624_3_1_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000801; Esterase-like.
DR Pfam; PF00756; Esterase; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Secreted; Signal; Transferase.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..299
FT /note="MPT51/MPB51 antigen"
FT /id="PRO_0000426744"
SQ SEQUENCE 299 AA; 31089 MW; 4E2E38F87AEDD73E CRC64;
MKGRSALLRA LWIAALSFGL GGVAVAAEPT AKAAPYENLM VPSPSMGRDI PVAFLAGGPH
AVYLLDAFNA GPDVSNWVTA GNAMNTLAGK GISVVAPAGG AYSMYTNWEQ DGSKQWDTFL
SAELPDWLAA NRGLAPGGHA AVGAAQGGYG AMALAAFHPD RFGFAGSMSG FLYPSNTTTN
GAIAAGMQQF GGVDTNGMWG APQLGRWKWH DPWVHASLLA QNNTRVWVWS PTNPGASDPA
AMIGQAAEAM GNSRMFYNQY RSVGGHNGHF DFPASGDNGW GSWAPQLGAM SGDIVGAIR