ID   MPTA1_METAR             Reviewed;         315 AA.
AC   Q0W6F5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=GTP cyclohydrolase MptA 1 {ECO:0000255|HAMAP-Rule:MF_01527};
DE            EC=3.5.4.39 {ECO:0000255|HAMAP-Rule:MF_01527};
DE   AltName: Full=GTP cyclohydrolase IV 1 {ECO:0000255|HAMAP-Rule:MF_01527};
GN   Name=mptA1 {ECO:0000255|HAMAP-Rule:MF_01527};
GN   OrderedLocusNames=UNCMA_21480; ORFNames=RCIX633;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic
CC       phosphate, the first intermediate in the biosynthesis of coenzyme
CC       methanopterin. {ECO:0000255|HAMAP-Rule:MF_01527}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = 7,8-dihydroneopterin 2',3'-cyclic phosphate +
CC         diphosphate + formate + H(+); Xref=Rhea:RHEA:25860,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:58854; EC=3.5.4.39;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01527};
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01527};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01527};
CC   -!- PATHWAY: Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin
CC       biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01527}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_01527}.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase IV family.
CC       {ECO:0000255|HAMAP-Rule:MF_01527}.
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DR   EMBL; AM114193; CAJ36038.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q0W6F5; -.
DR   SMR; Q0W6F5; -.
DR   STRING; 351160.RCIX633; -.
DR   EnsemblBacteria; CAJ36038; CAJ36038; RCIX633.
DR   KEGG; rci:RCIX633; -.
DR   PATRIC; fig|351160.9.peg.2198; -.
DR   eggNOG; arCOG04301; Archaea.
DR   OMA; ECQEVYD; -.
DR   UniPathway; UPA00065; -.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0003933; F:GTP cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01527_A; GTP_cyclohydrol_A; 1.
DR   InterPro; IPR003801; GTP_cyclohydrolase_FolE2/MptA.
DR   InterPro; IPR022840; GTP_cyclohydrolase_MptA.
DR   PANTHER; PTHR36445; PTHR36445; 1.
DR   Pfam; PF02649; GCHY-1; 1.
DR   TIGRFAMs; TIGR00294; TIGR00294; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Iron; Metal-binding; Reference proteome.
FT   CHAIN           1..315
FT                   /note="GTP cyclohydrolase MptA 1"
FT                   /id="PRO_0000289543"
FT   SITE            159
FT                   /note="May be catalytically important"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01527"
SQ   SEQUENCE   315 AA;  35410 MW;  57B4D83019EFE019 CRC64;
     MKFVQLPDVQ ASNPDVMVGL TRVGVTEVKK MVEITRSDKR PIILIPTFDI FVDLPSYRKG
     ANLSRNLEAI DRTLEEALNQ PVYRIEDLCV DVAKRLLETH EYASNAEVRM HGEYMMKKKS
     PKTGLECQEV YDIYADAIVV RGGIIRKTIG AKVIAMTACP CAQEISKETA FKKLAALGVA
     DNVIAEFLDD MPMPTHNQRG VGTIKIESGN DVKVSIEAII DIIENSMSSQ MYELLKREDE
     RYVVHSAHKN PKFVEDCVRT MAKNLVRKFP SLPDDAVITI EQVNEESIHR HNAFAERMAT
     FGELKKEMLS NGPVL