ARNE_SALTI
ID ARNE_SALTI Reviewed; 111 AA.
AC P81891;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 05-DEC-2001, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE {ECO:0000255|HAMAP-Rule:MF_01869};
DE Short=L-Ara4N-phosphoundecaprenol flippase subunit ArnE {ECO:0000255|HAMAP-Rule:MF_01869};
DE AltName: Full=Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE {ECO:0000255|HAMAP-Rule:MF_01869};
GN Name=arnE {ECO:0000255|HAMAP-Rule:MF_01869};
GN OrderedLocusNames=STY2532, t0561;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Ty2 / RMA2326;
RX PubMed=10075419; DOI=10.1099/13500872-145-2-367;
RA Baker S.J., Gunn J.S., Morona R.;
RT "The Salmonella typhi melittin resistance gene pqaB affects intracellular
RT growth in PMA-differentiated U937 cells, polymyxin B resistance and
RT lipopolysaccharide.";
RL Microbiology 145:367-378(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol
CC (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the
CC periplasmic side of the inner membrane. {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01869}.
CC -!- SUBUNIT: Heterodimer of ArnE and ArnF. {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01869}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
CC -!- SIMILARITY: Belongs to the ArnE family. {ECO:0000255|HAMAP-
CC Rule:MF_01869}.
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DR EMBL; AF071082; AAD20797.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD07535.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68267.1; -; Genomic_DNA.
DR RefSeq; NP_456845.1; NC_003198.1.
DR RefSeq; WP_000579483.1; NZ_WSUR01000039.1.
DR AlphaFoldDB; P81891; -.
DR SMR; P81891; -.
DR STRING; 220341.16503527; -.
DR TCDB; 2.A.7.22.2; the drug/metabolite transporter (dmt) superfamily.
DR EnsemblBacteria; AAO68267; AAO68267; t0561.
DR KEGG; stt:t0561; -.
DR KEGG; sty:STY2532; -.
DR PATRIC; fig|220341.7.peg.2563; -.
DR eggNOG; COG2076; Bacteria.
DR HOGENOM; CLU_131462_5_1_6; -.
DR OMA; TCAGQLC; -.
DR UniPathway; UPA00030; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:1901505; F:carbohydrate derivative transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR HAMAP; MF_01869; Flippase_ArnE; 1.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR022883; Flippase_ArnE.
DR InterPro; IPR000390; Small_drug/metabolite_transptr.
DR PANTHER; PTHR30561; PTHR30561; 1.
DR Pfam; PF00892; EamA; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Lipid A biosynthesis;
KW Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis;
KW Membrane; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..111
FT /note="Probable 4-amino-4-deoxy-L-arabinose-
FT phosphoundecaprenol flippase subunit ArnE"
FT /id="PRO_0000169185"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
FT DOMAIN 40..109
FT /note="EamA"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01869"
FT CONFLICT 90
FT /note="L -> P (in Ref. 1; AAD20797)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 111 AA; 12105 MW; 00F7DDB782D7E284 CRC64;
MIGIVLVLAS LLSVGGQLCQ KQATRPLTTG GRRRHLMLWL GLALICMGAA MVLWLLVLQT
LPVGIAYPML SLNFVWVTLA AWKIWHEQVL PRHWLGVALI ISGIIILGSA A
