ID   MPTD_PICTO              Reviewed;         120 AA.
AC   Q6L2J9;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Dihydroneopterin aldolase {ECO:0000255|HAMAP-Rule:MF_02130};
DE            Short=DHNA {ECO:0000255|HAMAP-Rule:MF_02130};
DE            EC=4.1.2.25 {ECO:0000255|HAMAP-Rule:MF_02130};
DE   AltName: Full=7,8-dihydroneopterin aldolase {ECO:0000255|HAMAP-Rule:MF_02130};
GN   Name=mptD {ECO:0000255|HAMAP-Rule:MF_02130}; OrderedLocusNames=PTO0218;
OS   Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC
OS   100828).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Picrophilaceae; Picrophilus.
OX   NCBI_TaxID=263820;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828;
RX   PubMed=15184674; DOI=10.1073/pnas.0401356101;
RA   Fuetterer O., Angelov A., Liesegang H., Gottschalk G., Schleper C.,
RA   Schepers B., Dock C., Antranikian G., Liebl W.;
RT   "Genome sequence of Picrophilus torridus and its implications for life
RT   around pH 0.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9091-9096(2004).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS) OF 2-120, AND SUBUNIT.
RG   New York structural genomix research consortium (NYSGXRC);
RT   "Structure of hypothetical protein PTO0218 from Picrophilus torridus.";
RL   Submitted (JUL-2011) to the PDB data bank.
CC   -!- FUNCTION: Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to
CC       6-hydroxymethyl-7,8-dihydropterin (6-HMD). {ECO:0000255|HAMAP-
CC       Rule:MF_02130}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin +
CC         glycolaldehyde; Xref=Rhea:RHEA:10540, ChEBI:CHEBI:17001,
CC         ChEBI:CHEBI:17071, ChEBI:CHEBI:44841; EC=4.1.2.25;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_02130};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_02130,
CC       ECO:0000269|Ref.2}.
CC   -!- SIMILARITY: Belongs to the archaeal dihydroneopterin aldolase family.
CC       {ECO:0000255|HAMAP-Rule:MF_02130}.
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DR   EMBL; AE017261; AAT42803.1; -; Genomic_DNA.
DR   RefSeq; WP_011177019.1; NC_005877.1.
DR   PDB; 2I52; X-ray; 2.08 A; A/B/C/D/E/F=2-120.
DR   PDBsum; 2I52; -.
DR   AlphaFoldDB; Q6L2J9; -.
DR   SMR; Q6L2J9; -.
DR   STRING; 263820.PTO0218; -.
DR   DNASU; 2844002; -.
DR   EnsemblBacteria; AAT42803; AAT42803; PTO0218.
DR   GeneID; 2844002; -.
DR   KEGG; pto:PTO0218; -.
DR   PATRIC; fig|263820.9.peg.236; -.
DR   eggNOG; arCOG04705; Archaea.
DR   HOGENOM; CLU_149105_1_0_2; -.
DR   OMA; FHQFVGT; -.
DR   OrthoDB; 110834at2157; -.
DR   EvolutionaryTrace; Q6L2J9; -.
DR   Proteomes; UP000000438; Chromosome.
DR   GO; GO:0004150; F:dihydroneopterin aldolase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1300.20; -; 1.
DR   HAMAP; MF_02130; DHNA_arch; 1.
DR   InterPro; IPR027508; DHN_aldolase_MptD.
DR   InterPro; IPR036839; MptD_sf.
DR   InterPro; IPR007181; MtpD_C.
DR   Pfam; PF04038; DHNA; 1.
DR   SUPFAM; SSF143560; SSF143560; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Lyase; Reference proteome.
FT   CHAIN           1..120
FT                   /note="Dihydroneopterin aldolase"
FT                   /id="PRO_0000420354"
FT   BINDING         20
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02130"
FT   BINDING         114
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_02130"
FT   HELIX           6..8
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   HELIX           13..32
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   TURN            39..41
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   HELIX           42..53
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   STRAND          59..66
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   TURN            83..85
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   STRAND          86..94
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   STRAND          97..106
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   TURN            107..110
FT                   /evidence="ECO:0007829|PDB:2I52"
FT   STRAND          111..119
FT                   /evidence="ECO:0007829|PDB:2I52"
SQ   SEQUENCE   120 AA;  13692 MW;  FE6A54DA26CF085F CRC64;
     MYDPAEKYFN CTDIQRAFFE AGIKLGAIFH QYTGIPVNSE NASMAEEFIE RSTMIQPFVE
     NVRISINNVK RSSGTYSYSS LNEKMLHAEV LINYNGKKVL GVLNYDEGLD YPVMYAKEVL