ID   MPTX_BOVIN              Reviewed;         217 AA.
AC   Q3T166;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Mucosal pentraxin;
DE   Flags: Precursor;
GN   Name=MPTX;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC       Note=Binds 2 calcium ions per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Homopentamer. Pentraxin (or pentaxin) have a discoid
CC       arrangement of 5 non-covalently bound subunits (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pentraxin family. {ECO:0000305}.
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DR   EMBL; BC102093; AAI02094.1; -; mRNA.
DR   RefSeq; NP_001029399.1; NM_001034227.2.
DR   AlphaFoldDB; Q3T166; -.
DR   SMR; Q3T166; -.
DR   STRING; 9913.ENSBTAP00000017120; -.
DR   PaxDb; Q3T166; -.
DR   PeptideAtlas; Q3T166; -.
DR   PRIDE; Q3T166; -.
DR   Ensembl; ENSBTAT00000017120; ENSBTAP00000017120; ENSBTAG00000012884.
DR   GeneID; 504879; -.
DR   KEGG; bta:504879; -.
DR   CTD; 649458; -.
DR   VEuPathDB; HostDB:ENSBTAG00000012884; -.
DR   VGNC; VGNC:108938; MPTX1.
DR   eggNOG; ENOG502S201; Eukaryota.
DR   GeneTree; ENSGT01050000244822; -.
DR   HOGENOM; CLU_032051_2_0_1; -.
DR   InParanoid; Q3T166; -.
DR   OMA; ASEHICA; -.
DR   OrthoDB; 1088298at2759; -.
DR   TreeFam; TF330208; -.
DR   Proteomes; UP000009136; Chromosome 3.
DR   Bgee; ENSBTAG00000012884; Expressed in caecum and 44 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0001849; F:complement component C1q complex binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR   CDD; cd00152; PTX; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR030476; Pentaxin_CS.
DR   InterPro; IPR001759; Pentraxin-related.
DR   Pfam; PF00354; Pentaxin; 1.
DR   PRINTS; PR00895; PENTAXIN.
DR   SMART; SM00159; PTX; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00289; PTX_1; 1.
DR   PROSITE; PS51828; PTX_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Disulfide bond; Metal-binding; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..217
FT                   /note="Mucosal pentraxin"
FT                   /id="PRO_0000342392"
FT   DOMAIN          24..217
FT                   /note="Pentraxin (PTX)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         77
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         78
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         155
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         155
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         156
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         157
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         157
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         167
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   DISULFID        55..114
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
SQ   SEQUENCE   217 AA;  24702 MW;  B6A7B2CFF8BD6310 CRC64;
     MEKLLLGVLL LAFLPEGMTQ KDLRGKVFIF PEQSDTAYVT LIPRVRKPLR SFTLCLKAFT
     DLTRPYSLFS YSTKSKDNEL LLFVNKVGEY ELHIGNTKVT FKVPRPPYGP VHLCVSWESV
     SGIAELWMNS RPVGRKGLRR GYTLGQDARI ILGQEQDSFG GKFDAKQSFV GEIWDVSLWD
     HVVSLKNLCF TCYTSNILNW KALIYQAKGY VVVKPKL