ID   MPTX_HUMAN              Reviewed;         137 AA.
AC   A8MV57;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Putative mucosal pentraxin homolog;
GN   Name=MPTX1; Synonyms=MPTX;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   IDENTIFICATION AS POSSIBLE PSEUDOGENE, AND TISSUE SPECIFICITY.
RX   PubMed=18850182; DOI=10.1007/s12263-007-0058-x;
RA   van der Meer-van Kraaij C., Siezen R., Kramer E., Reinders M., Blokzijl H.,
RA   van der Meer R., Keijer J.;
RT   "Dietary modulation and structure prediction of rat mucosal pentraxin
RT   (Mptx) protein and loss of function in humans.";
RL   Genes Nutr. 2:275-285(2007).
CC   -!- TISSUE SPECIFICITY: Not expressed in the intestinal tract including
CC       ascending colon, descending colon and rectum. Not expressed in the
CC       human colon cancer cell lines HT-29 and CaCo-2.
CC       {ECO:0000269|PubMed:18850182}.
CC   -!- SIMILARITY: Belongs to the pentraxin family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. Much shorter in N-
CC       terminus than its rodent counterparts due to a stop codon insertion.
CC       However, proteomics data suggest the existence of the protein.
CC       {ECO:0000305}.
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DR   EMBL; AL513323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8MV57; -.
DR   SMR; A8MV57; -.
DR   IntAct; A8MV57; 1.
DR   BioMuta; HGNC:48364; -.
DR   PRIDE; A8MV57; -.
DR   GeneCards; MPTX1; -.
DR   HGNC; HGNC:48364; MPTX1.
DR   neXtProt; NX_A8MV57; -.
DR   InParanoid; A8MV57; -.
DR   PhylomeDB; A8MV57; -.
DR   PathwayCommons; A8MV57; -.
DR   SignaLink; A8MV57; -.
DR   Pharos; A8MV57; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; A8MV57; protein.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001759; Pentraxin-related.
DR   Pfam; PF00354; Pentaxin; 1.
DR   PRINTS; PR00895; PENTAXIN.
DR   SMART; SM00159; PTX; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51828; PTX_2; 1.
PE   5: Uncertain;
KW   Calcium; Metal-binding; Reference proteome.
FT   CHAIN           1..137
FT                   /note="Putative mucosal pentraxin homolog"
FT                   /id="PRO_0000342395"
FT   DOMAIN          1..137
FT                   /note="Pentraxin (PTX)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         73
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         75
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   BINDING         85
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
SQ   SEQUENCE   137 AA;  15138 MW;  C074D3193906966B CRC64;
     MGMYLLHIGN AAVTFNGPTP CPRSPYASTH VNVSWESASG IATLWANGKL VGRKGVWKGY
     SVGEEAKIIL GQEQDSFGGH FDENQSFVGV IWDVFLWDHV LPPKEMCDSC YSGSLLNRHT
     LTYEDNGYVV TKPKVWA