MPTX_MOUSE
ID MPTX_MOUSE Reviewed; 219 AA.
AC Q8R1M8; Q9D8J8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Mucosal pentraxin;
DE Flags: Precursor;
GN Name=Mptx1; Synonyms=Mptx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=18850182; DOI=10.1007/s12263-007-0058-x;
RA van der Meer-van Kraaij C., Siezen R., Kramer E., Reinders M., Blokzijl H.,
RA van der Meer R., Keijer J.;
RT "Dietary modulation and structure prediction of rat mucosal pentraxin
RT (Mptx) protein and loss of function in humans.";
RL Genes Nutr. 2:275-285(2007).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence={ECO:0000250};
CC Note=Binds 2 calcium ions per subunit. {ECO:0000250};
CC -!- SUBUNIT: Homopentamer. Pentraxin (or pentaxin) have a discoid
CC arrangement of 5 non-covalently bound subunits (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in colon. {ECO:0000269|PubMed:18850182}.
CC -!- SIMILARITY: Belongs to the pentraxin family. {ECO:0000305}.
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DR EMBL; AK007963; BAB25374.1; -; mRNA.
DR EMBL; BC024348; AAH24348.1; -; mRNA.
DR RefSeq; NP_079746.1; NM_025470.3.
DR AlphaFoldDB; Q8R1M8; -.
DR SMR; Q8R1M8; -.
DR STRING; 10090.ENSMUSP00000027816; -.
DR GlyGen; Q8R1M8; 1 site.
DR MaxQB; Q8R1M8; -.
DR PRIDE; Q8R1M8; -.
DR ProteomicsDB; 291397; -.
DR DNASU; 66289; -.
DR GeneID; 66289; -.
DR KEGG; mmu:66289; -.
DR CTD; 649458; -.
DR MGI; MGI:1913539; Mptx1.
DR eggNOG; ENOG502S201; Eukaryota.
DR InParanoid; Q8R1M8; -.
DR OrthoDB; 1088298at2759; -.
DR PhylomeDB; Q8R1M8; -.
DR TreeFam; TF330208; -.
DR BioGRID-ORCS; 66289; 2 hits in 72 CRISPR screens.
DR PRO; PR:Q8R1M8; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8R1M8; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0001849; F:complement component C1q complex binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR CDD; cd00152; PTX; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001759; Pentraxin-related.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 2: Evidence at transcript level;
KW Calcium; Disulfide bond; Glycoprotein; Metal-binding; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..219
FT /note="Mucosal pentraxin"
FT /id="PRO_0000342393"
FT DOMAIN 24..219
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 77
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 78
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 155
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 155
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 156
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 157
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 157
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT BINDING 167
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT CARBOHYD 51
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 55..114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT CONFLICT 20
FT /note="Q -> E (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 58
FT /note="A -> T (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 75..76
FT /note="TK -> NQ (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="L -> M (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 100
FT /note="I -> T (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="V -> A (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="V -> G (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 139
FT /note="N -> K (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 151..152
FT /note="II -> TL (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 159
FT /note="F -> Y (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
FT CONFLICT 213
FT /note="I -> T (in Ref. 1; BAB25374)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 219 AA; 24538 MW; 4EB9FB2AE6178683 CRC64;
MEKLIVGILF LSVLSGSVAQ TDMKGKAFIF PQESSTAYVS LIPKVRKSLQ NFTLCMKAFT
DLTRPYSIFS YNTRTKDNEI LLFVENIGEY MFYVGNLVAI FKAPTNLPDP VRICVNWESV
SGIAEFWLNG KPLGRKGLNK GYTVGGDAMI IIGQEQDSFG GNFDAKQSFV GEIWDVSLWD
HVVPLEKVSD SCNNGNLINW QALNYEDNGY VVIKPKLWP
