MPU11_ARATH
ID MPU11_ARATH Reviewed; 239 AA.
AC Q9LTI3; Q8GXW3;
DT 08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Mannose-P-dolichol utilization defect 1 protein homolog 1;
GN OrderedLocusNames=At5g59470; ORFNames=F2O15.15, F2O15_130;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9LTI3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9LTI3-2; Sequence=VSP_038060, VSP_038061;
CC -!- SIMILARITY: Belongs to the MPDU1 (TC 2.A.43.3) family. {ECO:0000305}.
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DR EMBL; AB025604; BAA97482.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97193.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97194.1; -; Genomic_DNA.
DR EMBL; AK118007; BAC42640.1; -; mRNA.
DR EMBL; BT003664; AAO39892.1; -; mRNA.
DR RefSeq; NP_001190569.1; NM_001203640.2. [Q9LTI3-2]
DR RefSeq; NP_200755.1; NM_125338.3. [Q9LTI3-1]
DR AlphaFoldDB; Q9LTI3; -.
DR SMR; Q9LTI3; -.
DR STRING; 3702.AT5G59470.1; -.
DR PaxDb; Q9LTI3; -.
DR PRIDE; Q9LTI3; -.
DR ProteomicsDB; 250850; -. [Q9LTI3-1]
DR EnsemblPlants; AT5G59470.1; AT5G59470.1; AT5G59470. [Q9LTI3-1]
DR EnsemblPlants; AT5G59470.2; AT5G59470.2; AT5G59470. [Q9LTI3-2]
DR GeneID; 836066; -.
DR Gramene; AT5G59470.1; AT5G59470.1; AT5G59470. [Q9LTI3-1]
DR Gramene; AT5G59470.2; AT5G59470.2; AT5G59470. [Q9LTI3-2]
DR KEGG; ath:AT5G59470; -.
DR Araport; AT5G59470; -.
DR TAIR; locus:2148328; AT5G59470.
DR eggNOG; KOG3211; Eukaryota.
DR HOGENOM; CLU_053568_1_1_1; -.
DR InParanoid; Q9LTI3; -.
DR OMA; VIMMFAG; -.
DR OrthoDB; 1059579at2759; -.
DR PhylomeDB; Q9LTI3; -.
DR PRO; PR:Q9LTI3; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LTI3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR016817; MannP-dilichol_defect-1.
DR InterPro; IPR006603; PQ-loop_rpt.
DR PANTHER; PTHR12226; PTHR12226; 1.
DR Pfam; PF04193; PQ-loop; 2.
DR PIRSF; PIRSF023381; MannP-dilichol_defect-1p; 1.
DR SMART; SM00679; CTNS; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..239
FT /note="Mannose-P-dolichol utilization defect 1 protein
FT homolog 1"
FT /id="PRO_0000221038"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 27..93
FT /note="PQ-loop 1"
FT DOMAIN 150..205
FT /note="PQ-loop 2"
FT VAR_SEQ 136..148
FT /note="GKIDPFLFEALYA -> DLEELQKQKHWTT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074,
FT ECO:0000303|PubMed:14593172"
FT /id="VSP_038060"
FT VAR_SEQ 149..239
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074,
FT ECO:0000303|PubMed:14593172"
FT /id="VSP_038061"
SQ SEQUENCE 239 AA; 26419 MW; 209FF0E25F3E6E2F CRC64;
MDYLGIDLSC AIGSLRNGEF PAKDCLLPLI SKLLGYFLVA ASMTVKLPQI MKIVDNKSVK
GLSVVAFELE VIGYTISLAY CLNKDLPFSA FGELAFLLIQ ALILVACIYY FSQPLSVTTW
VKAILYFAIA PTVFAGKIDP FLFEALYASK HLIFLSARIP QIWKNFRNKS TGQLSFLTCL
MNFGGALARV FTSIQEKAPL SMLLGIVLSI FTNGIIMSQI LLYRSKGNED KLVKSKKIS
