MPU12_ARATH
ID MPU12_ARATH Reviewed; 235 AA.
AC Q8VY63; Q8LD25; Q9S9X5;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Mannose-P-dolichol utilization defect 1 protein homolog 2;
GN OrderedLocusNames=At4g07390; ORFNames=F28D6.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for normal utilization of mannose-dolichol phosphate
CC (Dol-P-Man) in the synthesis of N-linked and O-linked oligosaccharides
CC and GPI anchors. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MPDU1 (TC 2.A.43.3) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD48939.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB81109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF147262; AAD48939.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161505; CAB81109.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE82564.1; -; Genomic_DNA.
DR EMBL; CP002687; ANM66935.1; -; Genomic_DNA.
DR EMBL; AY072415; AAL62407.1; -; mRNA.
DR EMBL; AY114712; AAM48031.1; -; mRNA.
DR EMBL; AY086246; AAM64321.1; -; mRNA.
DR PIR; A85072; A85072.
DR RefSeq; NP_001328799.1; NM_001340563.1.
DR RefSeq; NP_567315.1; NM_116811.3.
DR AlphaFoldDB; Q8VY63; -.
DR SMR; Q8VY63; -.
DR STRING; 3702.AT4G07390.1; -.
DR PaxDb; Q8VY63; -.
DR PRIDE; Q8VY63; -.
DR ProteomicsDB; 250851; -.
DR EnsemblPlants; AT4G07390.1; AT4G07390.1; AT4G07390.
DR EnsemblPlants; AT4G07390.2; AT4G07390.2; AT4G07390.
DR GeneID; 826170; -.
DR Gramene; AT4G07390.1; AT4G07390.1; AT4G07390.
DR Gramene; AT4G07390.2; AT4G07390.2; AT4G07390.
DR KEGG; ath:AT4G07390; -.
DR Araport; AT4G07390; -.
DR TAIR; locus:2124367; AT4G07390.
DR eggNOG; KOG3211; Eukaryota.
DR HOGENOM; CLU_053568_1_1_1; -.
DR InParanoid; Q8VY63; -.
DR OMA; AGFWIIL; -.
DR OrthoDB; 1059579at2759; -.
DR PhylomeDB; Q8VY63; -.
DR PRO; PR:Q8VY63; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q8VY63; baseline and differential.
DR Genevisible; Q8VY63; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR016817; MannP-dilichol_defect-1.
DR InterPro; IPR006603; PQ-loop_rpt.
DR PANTHER; PTHR12226; PTHR12226; 1.
DR Pfam; PF04193; PQ-loop; 2.
DR PIRSF; PIRSF023381; MannP-dilichol_defect-1p; 1.
DR SMART; SM00679; CTNS; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..235
FT /note="Mannose-P-dolichol utilization defect 1 protein
FT homolog 2"
FT /id="PRO_0000415738"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..222
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 27..93
FT /note="PQ-loop 1"
FT DOMAIN 150..205
FT /note="PQ-loop 2"
FT CONFLICT 135
FT /note="A -> S (in Ref. 4; AAM64321)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 235 AA; 25799 MW; ED07DC1D0B17D03B CRC64;
MDYLGIDMSC AIGSLRNGDF PEKDCLLPLI SKLLGYCLVA ASITVKLPQI MKIVQHKSVR
GLSVVAFELE VVGYTISLAY CLHKGLPFSA FGEMAFLLIQ ALILVACIYY YSQPVPVTTW
IRPLLYCAVA PTVLAGQINP TLFEALYASQ HAIFLFARLP QIWKNFKNKS TGELSFLTFF
MNFAGSIVRV FTSLQEKAPI SILTGFALGV VTNGSILTQI LLYSKPAAAK EKKAN
