MPU1_CAEEL
ID MPU1_CAEEL Reviewed; 242 AA.
AC Q20157;
DT 08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 18-SEP-2013, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Mannose-P-dolichol utilization defect 1 protein homolog;
GN Name=mpdu-1 {ECO:0000312|WormBase:F38E1.9};
GN ORFNames=F38E1.9 {ECO:0000312|WormBase:F38E1.9};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MPDU1 (TC 2.A.43.3) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284605; CCD63661.2; -; Genomic_DNA.
DR PIR; T34255; T34255.
DR RefSeq; NP_505155.2; NM_072754.6.
DR AlphaFoldDB; Q20157; -.
DR SMR; Q20157; -.
DR STRING; 6239.F38E1.9; -.
DR EPD; Q20157; -.
DR PaxDb; Q20157; -.
DR PeptideAtlas; Q20157; -.
DR EnsemblMetazoa; F38E1.9.1; F38E1.9.1; WBGene00018181.
DR GeneID; 179218; -.
DR KEGG; cel:CELE_F38E1.9; -.
DR UCSC; F38E1.9; c. elegans.
DR CTD; 179218; -.
DR WormBase; F38E1.9; CE47834; WBGene00018181; mpdu-1.
DR eggNOG; KOG3211; Eukaryota.
DR GeneTree; ENSGT00940000153916; -.
DR HOGENOM; CLU_053568_2_0_1; -.
DR InParanoid; Q20157; -.
DR OMA; VIMMFAG; -.
DR OrthoDB; 1059579at2759; -.
DR PhylomeDB; Q20157; -.
DR Reactome; R-CEL-446193; Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.
DR PRO; PR:Q20157; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00018181; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009312; P:oligosaccharide biosynthetic process; IBA:GO_Central.
DR InterPro; IPR016817; MannP-dilichol_defect-1.
DR InterPro; IPR006603; PQ-loop_rpt.
DR PANTHER; PTHR12226; PTHR12226; 1.
DR Pfam; PF04193; PQ-loop; 2.
DR PIRSF; PIRSF023381; MannP-dilichol_defect-1p; 1.
DR SMART; SM00679; CTNS; 2.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..242
FT /note="Mannose-P-dolichol utilization defect 1 protein
FT homolog"
FT /id="PRO_0000221036"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 98..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 37..95
FT /note="PQ-loop 1"
FT DOMAIN 152..202
FT /note="PQ-loop 2"
SQ SEQUENCE 242 AA; 26061 MW; FA4A89379D533E9C CRC64;
MSKIMNDIIQ SLFPGNCFEE LLINFNFFHP TCPKAVLSRG LGFAITLGSI LLFVPQILKI
QAARSAQGIS AASQLLALVG AIGTASYSYR SGFVFSGWGD SFFVAVQLVI IILQIFLFSG
QTMLSVGFLG IVSAVAYGVV SKSIPMQTLT AVQTAGIPIV VVSKLLQISQ NYRAQSTGQL
SLISVFLQFA GTLARVFTSV QDTGDMLLIV SYSTAAVLNG LIFAQFFMYW SHSESAAKKK
RN
