ID   MPV17_RAT               Reviewed;         176 AA.
AC   Q5BK62;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Protein Mpv17;
GN   Name=Mpv17; Synonyms=Mpv17l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Non-selective channel that modulates the membrane potential
CC       under normal conditions and oxidative stress, and is involved in
CC       mitochondrial homeostasis. Involved in mitochondrial deoxynucleoside
CC       triphosphates (dNTP) pool homeostasis and mitochondrial DNA (mtDNA)
CC       maintenance (By similarity). May be involved in the regulation of
CC       reactive oxygen species metabolism and the control of oxidative
CC       phosphorylation (By similarity). {ECO:0000250|UniProtKB:P19258,
CC       ECO:0000250|UniProtKB:P39210}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P39210}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P39210}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; BC091193; AAH91193.1; -; mRNA.
DR   RefSeq; NP_001091710.1; NM_001098240.1.
DR   AlphaFoldDB; Q5BK62; -.
DR   STRING; 10116.ENSRNOP00000037647; -.
DR   PhosphoSitePlus; Q5BK62; -.
DR   PaxDb; Q5BK62; -.
DR   PRIDE; Q5BK62; -.
DR   GeneID; 360463; -.
DR   KEGG; rno:360463; -.
DR   CTD; 4358; -.
DR   RGD; 1310512; Mpv17.
DR   eggNOG; KOG1944; Eukaryota.
DR   InParanoid; Q5BK62; -.
DR   OrthoDB; 1324608at2759; -.
DR   Reactome; R-RNO-9033241; Peroxisomal protein import.
DR   PRO; PR:Q5BK62; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISO:RGD.
DR   GO; GO:0005739; C:mitochondrion; ISO:RGD.
DR   GO; GO:0005777; C:peroxisome; ISO:RGD.
DR   GO; GO:0015267; F:channel activity; ISS:UniProtKB.
DR   GO; GO:0034614; P:cellular response to reactive oxygen species; ISO:RGD.
DR   GO; GO:0032836; P:glomerular basement membrane development; ISO:RGD.
DR   GO; GO:0042592; P:homeostatic process; ISO:RGD.
DR   GO; GO:0048839; P:inner ear development; ISO:RGD.
DR   GO; GO:0000002; P:mitochondrial genome maintenance; ISO:RGD.
DR   GO; GO:0072593; P:reactive oxygen species metabolic process; ISO:RGD.
DR   GO; GO:1901858; P:regulation of mitochondrial DNA metabolic process; ISS:UniProtKB.
DR   GO; GO:2000377; P:regulation of reactive oxygen species metabolic process; ISO:RGD.
DR   GO; GO:0007605; P:sensory perception of sound; ISO:RGD.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..176
FT                   /note="Protein Mpv17"
FT                   /id="PRO_0000234399"
FT   TRANSMEM        18..38
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        94..114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   SITE            92
FT                   /note="Determines ion selectivity"
FT                   /evidence="ECO:0000250|UniProtKB:P39210"
SQ   SEQUENCE   176 AA;  19627 MW;  1284B5DBC06D68FA CRC64;
     MALWRAYQRA LAAHPWKVQV LTAGSLMGLG DIISQQLVER RGLQQHQTGR TLTMASLGCG
     FVGPVVGGWY RVLDHLIPGT TKVNALKKML LDQGGFAPCF LGCFLPLVGV LNGMSAQDNW
     AKLKRDYPDA LITNYYLWPA VQLANFYLVP LHYRLAVVQC VAVVWNSYLS WKAHQL