ID   MPV17_XENLA             Reviewed;         177 AA.
AC   Q66GV0;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Protein Mpv17;
GN   Name=mpv17;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in mitochondrial homeostasis, and control of
CC       oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (By
CC       similarity). Non-selective channel that modulates the membrane
CC       potential under normal conditions and oxidative stress (By similarity).
CC       {ECO:0000250|UniProtKB:P39210, ECO:0000250|UniProtKB:Q5TZ51}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:Q5TZ51}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q5TZ51}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH82223.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC082223; AAH82223.1; ALT_INIT; mRNA.
DR   RefSeq; XP_018117688.1; XM_018262199.1.
DR   AlphaFoldDB; Q66GV0; -.
DR   PRIDE; Q66GV0; -.
DR   GeneID; 446961; -.
DR   CTD; 446961; -.
DR   Xenbase; XB-GENE-6254843; mpv17.L.
DR   OrthoDB; 1324608at2759; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 446961; Expressed in testis and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..177
FT                   /note="Protein Mpv17"
FT                   /id="PRO_0000234401"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   SITE            93
FT                   /note="Determines ion selectivity"
FT                   /evidence="ECO:0000250|UniProtKB:P39210"
SQ   SEQUENCE   177 AA;  19748 MW;  BE95571A3A4BD1AF CRC64;
     MAGLWRAYQR LLGAHPWKVQ IVTAGSLVGV GDVISQQLLE RKGLKGHSIE RTVKMMGIGF
     CFVGPVVGGW YKILDRIIPG SGKPVALKKM LLDQVAFAPC FLGCFLSIAS ALNGLSGEQI
     WGKLKRDYKD ALITNYYIWP AVQVANFYFI PLYHRLAVVQ FVAIIWNSYL SWKANKS