ID   MPZL2_BOVIN             Reviewed;         215 AA.
AC   Q5EAB0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Myelin protein zero-like protein 2;
DE   AltName: Full=Epithelial V-like antigen 1;
DE   Flags: Precursor;
GN   Name=MPZL2; Synonyms=EVA1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates homophilic cell-cell adhesion. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the myelin P0 protein family. {ECO:0000305}.
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DR   EMBL; BT020659; AAX08676.1; -; mRNA.
DR   EMBL; BC102486; AAI02487.1; -; mRNA.
DR   RefSeq; NP_001015673.1; NM_001015673.2.
DR   AlphaFoldDB; Q5EAB0; -.
DR   SMR; Q5EAB0; -.
DR   STRING; 9913.ENSBTAP00000001633; -.
DR   PaxDb; Q5EAB0; -.
DR   Ensembl; ENSBTAT00000001633; ENSBTAP00000001633; ENSBTAG00000033510.
DR   GeneID; 540423; -.
DR   KEGG; bta:540423; -.
DR   CTD; 10205; -.
DR   VEuPathDB; HostDB:ENSBTAG00000033510; -.
DR   VGNC; VGNC:31593; MPZL2.
DR   eggNOG; ENOG502RYWU; Eukaryota.
DR   GeneTree; ENSGT01030000234556; -.
DR   HOGENOM; CLU_090350_0_0_1; -.
DR   InParanoid; Q5EAB0; -.
DR   OMA; DVSIIIW; -.
DR   OrthoDB; 1214335at2759; -.
DR   TreeFam; TF331728; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000033510; Expressed in rumen papilla and 98 other tissues.
DR   ExpressionAtlas; Q5EAB0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR029863; MPZL2.
DR   InterPro; IPR000920; Myelin_P0-rel.
DR   PANTHER; PTHR13869; PTHR13869; 1.
DR   PANTHER; PTHR13869:SF21; PTHR13869:SF21; 1.
DR   Pfam; PF07686; V-set; 1.
DR   PRINTS; PR00213; MYELINP0.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..215
FT                   /note="Myelin protein zero-like protein 2"
FT                   /id="PRO_0000283718"
FT   TOPO_DOM        27..154
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..215
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          27..141
FT                   /note="Ig-like V-type"
FT   CARBOHYD        39
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        47..123
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   215 AA;  24456 MW;  CB0557BEAA3C678E CRC64;
     MYGKSPTRAV LFLLGLQLTA LWPTAAVEIY TPRVLEAVNG TDVRLKCTFS SFAPVGDALT
     VTWNFRPRDG GPEQFVFYYH VDPFKPMSGR FKDRVAWDGN PERYDVSILL WKLQFDDNGT
     YTCQVKNPPD VDGLIGEIQL SVVQTVRFSE IHFLALAIGS ACALMVIIVI VVVLFQHFRK
     KRRAERAHRV VEIKSKEEEK LNQEKKASVS LEYTD