ID   MPZL2_PONAB             Reviewed;         214 AA.
AC   Q5R804;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Myelin protein zero-like protein 2;
DE   AltName: Full=Epithelial V-like antigen 1;
DE   Flags: Precursor;
GN   Name=MPZL2; Synonyms=EVA1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates homophilic cell-cell adhesion. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the myelin P0 protein family. {ECO:0000305}.
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DR   EMBL; CR859288; CAH91466.1; -; mRNA.
DR   EMBL; CR859952; CAH92106.1; -; mRNA.
DR   RefSeq; NP_001125862.1; NM_001132390.1.
DR   AlphaFoldDB; Q5R804; -.
DR   SMR; Q5R804; -.
DR   STRING; 9601.ENSPPYP00000004499; -.
DR   GeneID; 100172793; -.
DR   KEGG; pon:100172793; -.
DR   CTD; 10205; -.
DR   eggNOG; ENOG502RYWU; Eukaryota.
DR   InParanoid; Q5R804; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR029863; MPZL2.
DR   InterPro; IPR000920; Myelin_P0-rel.
DR   PANTHER; PTHR13869; PTHR13869; 1.
DR   PANTHER; PTHR13869:SF21; PTHR13869:SF21; 1.
DR   Pfam; PF07686; V-set; 1.
DR   PRINTS; PR00213; MYELINP0.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..214
FT                   /note="Myelin protein zero-like protein 2"
FT                   /id="PRO_0000042932"
FT   TOPO_DOM        26..151
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        173..214
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          26..140
FT                   /note="Ig-like V-type"
FT   CARBOHYD        38
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        46..122
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   214 AA;  24405 MW;  6974260E0FDF3E51 CRC64;
     MYGKSSTRAV LLLGIQLTAI WPIAAVEIYT SRVLEAVNGT DARLKCTFSS FAPVGDALTV
     TWNFRPLDGG PEQFVFYYHI DPFQPMSGRF KDRVSWDGNP ERYDASIFLW KLQFDDNGTY
     TCQVKNPPDV DGVIGEIRLS VVHTVRFSEI HFLALAIGSA CALMIIIVIV VVLFQHYRKK
     RWAERAHKVV EIKSKEEERL NQEKKVSVYL EDTD