ID   MPZL3_BOVIN             Reviewed;         234 AA.
AC   A5D7C3;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Myelin protein zero-like protein 3;
DE   Flags: Precursor;
GN   Name=MPZL3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates homophilic cell-cell adhesion. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the myelin P0 protein family. {ECO:0000305}.
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DR   EMBL; BC140504; AAI40505.1; -; mRNA.
DR   RefSeq; NP_001091520.1; NM_001098051.1.
DR   AlphaFoldDB; A5D7C3; -.
DR   SMR; A5D7C3; -.
DR   STRING; 9913.ENSBTAP00000001630; -.
DR   PaxDb; A5D7C3; -.
DR   PRIDE; A5D7C3; -.
DR   Ensembl; ENSBTAT00000001630; ENSBTAP00000001630; ENSBTAG00000001233.
DR   GeneID; 521837; -.
DR   KEGG; bta:521837; -.
DR   CTD; 196264; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001233; -.
DR   VGNC; VGNC:31594; MPZL3.
DR   eggNOG; ENOG502RYH4; Eukaryota.
DR   GeneTree; ENSGT01030000234556; -.
DR   InParanoid; A5D7C3; -.
DR   OMA; FFQGVHI; -.
DR   OrthoDB; 1437254at2759; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000001233; Expressed in rumen papilla and 105 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR   GO; GO:0042633; P:hair cycle; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR029862; MPZL3.
DR   InterPro; IPR000920; Myelin_P0-rel.
DR   PANTHER; PTHR13869; PTHR13869; 1.
DR   PANTHER; PTHR13869:SF20; PTHR13869:SF20; 1.
DR   Pfam; PF07686; V-set; 1.
DR   PRINTS; PR00213; MYELINP0.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000250"
FT   CHAIN           32..234
FT                   /note="Myelin protein zero-like protein 3"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000312853"
FT   TOPO_DOM        32..158
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          32..148
FT                   /note="Ig-like V-type"
FT   CARBOHYD        123
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        52..128
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   234 AA;  25756 MW;  4F08ED6DAD9039D4 CRC64;
     MQQSGVPGSR GCALCPLLGV LFFQGVYVIF SLEIKADAHV RGYVGENIKL RCTFKSSSSI
     TDKLTIDWTY RPPSSSRTES IFHYQSFQYP TTAGTFRDRI SWVGDVYKGD ASISISNPTM
     KDNGTFSCAV KNPPDVHHNI PATELTVTER GFGTMLSSVA LLSILVFIPS TVVVILLLVR
     MGRKSAGLKK RSKSGYKKSS IEVSDDTDQE GDDCMAKLCV RCAECVDSDY EETY