MPZL3_HUMAN
ID MPZL3_HUMAN Reviewed; 235 AA.
AC Q6UWV2; A8K025; B4DLD5; B4E2I8;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Myelin protein zero-like protein 3;
DE Flags: Precursor;
GN Name=MPZL3; ORFNames=UNQ2966/PRO7425;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Tongue, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 32-46.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: Mediates homophilic cell-cell adhesion. {ECO:0000250}.
CC -!- INTERACTION:
CC Q6UWV2; O60487: MPZL2; NbExp=3; IntAct=EBI-4314854, EBI-3906725;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6UWV2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWV2-2; Sequence=VSP_053988;
CC Name=3;
CC IsoId=Q6UWV2-3; Sequence=VSP_055324, VSP_055325;
CC -!- SIMILARITY: Belongs to the myelin P0 protein family. {ECO:0000305}.
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DR EMBL; AY358626; AAQ88989.1; -; mRNA.
DR EMBL; AK289390; BAF82079.1; -; mRNA.
DR EMBL; AK095399; BAG53045.1; -; mRNA.
DR EMBL; AK296951; BAG59497.1; -; mRNA.
DR EMBL; AK304292; BAG65150.1; -; mRNA.
DR EMBL; AP002800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67357.1; -; Genomic_DNA.
DR EMBL; BC113586; AAI13587.1; -; mRNA.
DR EMBL; BC143897; AAI43898.1; -; mRNA.
DR CCDS; CCDS66241.1; -. [Q6UWV2-2]
DR CCDS; CCDS8392.1; -. [Q6UWV2-1]
DR RefSeq; NP_001273081.1; NM_001286152.1. [Q6UWV2-2]
DR RefSeq; NP_938016.1; NM_198275.2. [Q6UWV2-1]
DR AlphaFoldDB; Q6UWV2; -.
DR SMR; Q6UWV2; -.
DR BioGRID; 128193; 5.
DR IntAct; Q6UWV2; 3.
DR STRING; 9606.ENSP00000278949; -.
DR GlyGen; Q6UWV2; 1 site.
DR iPTMnet; Q6UWV2; -.
DR PhosphoSitePlus; Q6UWV2; -.
DR BioMuta; MPZL3; -.
DR DMDM; 74758560; -.
DR EPD; Q6UWV2; -.
DR jPOST; Q6UWV2; -.
DR MassIVE; Q6UWV2; -.
DR PaxDb; Q6UWV2; -.
DR PeptideAtlas; Q6UWV2; -.
DR PRIDE; Q6UWV2; -.
DR ProteomicsDB; 5822; -.
DR ProteomicsDB; 67527; -. [Q6UWV2-1]
DR Antibodypedia; 32439; 95 antibodies from 17 providers.
DR DNASU; 196264; -.
DR Ensembl; ENST00000278949.9; ENSP00000278949.4; ENSG00000160588.10. [Q6UWV2-1]
DR Ensembl; ENST00000446386.2; ENSP00000393594.2; ENSG00000160588.10. [Q6UWV2-3]
DR Ensembl; ENST00000527472.1; ENSP00000432106.1; ENSG00000160588.10. [Q6UWV2-2]
DR GeneID; 196264; -.
DR KEGG; hsa:196264; -.
DR MANE-Select; ENST00000278949.9; ENSP00000278949.4; NM_198275.3; NP_938016.1.
DR UCSC; uc001psm.5; human. [Q6UWV2-1]
DR CTD; 196264; -.
DR DisGeNET; 196264; -.
DR GeneCards; MPZL3; -.
DR HGNC; HGNC:27279; MPZL3.
DR HPA; ENSG00000160588; Tissue enhanced (esophagus, skin).
DR MIM; 611707; gene.
DR neXtProt; NX_Q6UWV2; -.
DR OpenTargets; ENSG00000160588; -.
DR PharmGKB; PA162396160; -.
DR VEuPathDB; HostDB:ENSG00000160588; -.
DR eggNOG; ENOG502RYH4; Eukaryota.
DR GeneTree; ENSGT01030000234556; -.
DR HOGENOM; CLU_090350_1_0_1; -.
DR InParanoid; Q6UWV2; -.
DR OMA; FFQGVHI; -.
DR OrthoDB; 1437254at2759; -.
DR PhylomeDB; Q6UWV2; -.
DR TreeFam; TF331728; -.
DR PathwayCommons; Q6UWV2; -.
DR SignaLink; Q6UWV2; -.
DR BioGRID-ORCS; 196264; 9 hits in 1071 CRISPR screens.
DR ChiTaRS; MPZL3; human.
DR GenomeRNAi; 196264; -.
DR Pharos; Q6UWV2; Tbio.
DR PRO; PR:Q6UWV2; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6UWV2; protein.
DR Bgee; ENSG00000160588; Expressed in buccal mucosa cell and 135 other tissues.
DR ExpressionAtlas; Q6UWV2; baseline and differential.
DR Genevisible; Q6UWV2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0042633; P:hair cycle; IEA:Ensembl.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR029862; MPZL3.
DR InterPro; IPR000920; Myelin_P0-rel.
DR PANTHER; PTHR13869; PTHR13869; 1.
DR PANTHER; PTHR13869:SF20; PTHR13869:SF20; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR00213; MYELINP0.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell adhesion; Direct protein sequencing;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane;
KW Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000269|PubMed:15340161"
FT CHAIN 32..235
FT /note="Myelin protein zero-like protein 3"
FT /id="PRO_0000280282"
FT TOPO_DOM 32..158
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..235
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 32..148
FT /note="Ig-like V-type"
FT CARBOHYD 123
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 52..128
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 25..36
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_053988"
FT VAR_SEQ 81..108
FT /note="IFHYQSFQYPTTAGTFRDRISWVGNVYK -> VLAPCFPLWPFFPSLSLCPQ
FT PWWLLCCW (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055324"
FT VAR_SEQ 109..235
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055325"
FT VARIANT 155
FT /note="M -> V (in dbSNP:rs17121966)"
FT /id="VAR_031108"
FT VARIANT 168
FT /note="V -> G (in dbSNP:rs36102742)"
FT /id="VAR_050455"
FT VARIANT 172
FT /note="V -> M (in dbSNP:rs34507994)"
FT /id="VAR_050456"
FT VARIANT 228
FT /note="D -> V (in dbSNP:rs7105729)"
FT /id="VAR_031109"
SQ SEQUENCE 235 AA; 25989 MW; 009B7ED8C82C7B4F CRC64;
MQQRGAAGSR GCALFPLLGV LFFQGVYIVF SLEIRADAHV RGYVGEKIKL KCTFKSTSDV
TDKLTIDWTY RPPSSSHTVS IFHYQSFQYP TTAGTFRDRI SWVGNVYKGD ASISISNPTI
KDNGTFSCAV KNPPDVHHNI PMTELTVTER GFGTMLSSVA LLSILVFVPS AVVVALLLVR
MGRKAAGLKK RSRSGYKKSS IEVSDDTDQE EEEACMARLC VRCAECLDSD YEETY
