ID   MPZL3_XENLA             Reviewed;         229 AA.
AC   Q8AVM3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Myelin protein zero-like protein 3;
DE   Flags: Precursor;
GN   Name=mpzl3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates homophilic cell-cell adhesion. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the myelin P0 protein family. {ECO:0000305}.
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DR   EMBL; BC041735; AAH41735.1; -; mRNA.
DR   RefSeq; NP_001079418.1; NM_001085949.1.
DR   AlphaFoldDB; Q8AVM3; -.
DR   SMR; Q8AVM3; -.
DR   DNASU; 379105; -.
DR   GeneID; 379105; -.
DR   KEGG; xla:379105; -.
DR   CTD; 379105; -.
DR   Xenbase; XB-GENE-6078905; mpzl3.L.
DR   OrthoDB; 1437254at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 379105; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR029862; MPZL3.
DR   InterPro; IPR000920; Myelin_P0-rel.
DR   PANTHER; PTHR13869; PTHR13869; 1.
DR   PANTHER; PTHR13869:SF20; PTHR13869:SF20; 1.
DR   Pfam; PF07686; V-set; 1.
DR   PRINTS; PR00213; MYELINP0.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..229
FT                   /note="Myelin protein zero-like protein 3"
FT                   /id="PRO_0000280284"
FT   TOPO_DOM        17..143
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        165..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          17..131
FT                   /note="Ig-like V-type"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..113
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   229 AA;  25865 MW;  986A3F14B8261665 CRC64;
     MWVLILLLAG MPPVLCIDIS MHPDAFGVVG KSIKLKCSFT SSYPISDIVA VDWTYRQLNG
     GSTVTILHFQ NKPYPILEGP FKDRIIWEGD VRRGDASISL TDLRLTDNGT LSCIVWNPPD
     VHGNVPQTKL TVTIENLFFQ FNTVILLSAL VFIPSALVSL LLLIRMRRSI NRGRTKNLKW
     RKKSPIEESQ DCVYDDNENT PLHPTLPQEQ SPGCFMKFCL RCLDDSDED