MP_PINMA
ID MP_PINMA Reviewed; 260 AA.
AC P86948;
DT 19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 1.
DT 03-AUG-2022, entry version 16.
DE RecName: Full=Mantle protein;
DE Short=MP;
DE Flags: Precursor;
OS Pinctada maxima (Silver-lipped pearl oyster) (White-lipped pearl oyster).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC Autobranchia; Pteriomorphia; Pterioida; Pterioidea; Pteriidae; Pinctada.
OX NCBI_TaxID=104660;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND IDENTIFICATION.
RC TISSUE=Mantle {ECO:0000269|PubMed:19915030};
RX PubMed=19915030; DOI=10.1093/molbev/msp278;
RA Jackson D.J., McDougall C., Woodcroft B., Moase P., Rose R.A., Kube M.,
RA Reinhardt R., Rokhsar D.S., Montagnani C., Joubert C., Piquemal D.,
RA Degnan B.M.;
RT "Parallel evolution of nacre building gene sets in molluscs.";
RL Mol. Biol. Evol. 27:591-608(2010).
RN [2]
RP PROTEIN SEQUENCE OF 60-69; 118-125; 129-138; 153-164; 166-181; 193-199 AND
RP 216-228, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Shell;
RX PubMed=23213212; DOI=10.1073/pnas.1210552109;
RA Marie B., Joubert C., Tayale A., Zanella-Cleon I., Belliard C.,
RA Piquemal D., Cochennec-Laureau N., Marin F., Gueguen Y., Montagnani C.;
RT "Different secretory repertoires control the biomineralization processes of
RT prism and nacre deposition of the pearl oyster shell.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:20986-20991(2012).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23213212}.
CC -!- TISSUE SPECIFICITY: Prismatic layer of shell (at protein level).
CC Expressed primarily in the mantle with highest level in the mantle edge
CC and lower level in the mantle pallium. {ECO:0000269|PubMed:23213212}.
CC -!- SEQUENCE CAUTION:
CC Sequence=GT279654; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT279783; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=GT281217; Type=Miscellaneous discrepancy; Note=Premature stop codon at position 215.; Evidence={ECO:0000305};
CC Sequence=GT281270; Type=Miscellaneous discrepancy; Note=Premature stop codon at position 128.; Evidence={ECO:0000305};
CC Sequence=GT281750; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; GT277755; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT277821; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT278407; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279048; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279510; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279654; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279655; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT279783; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281217; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281270; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT281750; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282426; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT282750; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283077; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283189; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283412; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; GT283426; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; EZ420146; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P86948; -.
DR PRIDE; P86948; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..260
FT /note="Mantle protein"
FT /evidence="ECO:0000255"
FT /id="PRO_0000413082"
FT CONFLICT 47
FT /note="V -> F (in Ref. 1; GT277821)"
FT /evidence="ECO:0000305"
FT CONFLICT 67
FT /note="V -> I (in Ref. 1; GT277755)"
FT /evidence="ECO:0000305"
FT CONFLICT 84
FT /note="R -> K (in Ref. 1; GT277755)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="V -> D (in Ref. 1; GT277755)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="V -> D (in Ref. 1; GT277755)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="D -> Y (in Ref. 1; GT277755)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="R -> T (in Ref. 1; GT283189)"
FT /evidence="ECO:0000305"
FT CONFLICT 150
FT /note="E -> Q (in Ref. 1; GT283189)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="R -> T (in Ref. 1; GT283189)"
FT /evidence="ECO:0000305"
FT CONFLICT 157
FT /note="R -> K (in Ref. 1; GT282426)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="V -> L (in Ref. 1; GT279048)"
FT /evidence="ECO:0000305"
FT CONFLICT 185..186
FT /note="RP -> KT (in Ref. 1; GT279048)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="R -> K (in Ref. 1; GT282426)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="R -> K (in Ref. 1; GT279510/GT282426)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="V -> S (in Ref. 1; GT281217)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 29812 MW; B5F1128D3DC0A72F CRC64;
MLAVLLFAAL VATAYSQEYG PAKPDVKIIP HPKTVVHEDA RHVHRQVHLV KQVPVHRTRV
QTIINEVPRI IRKPKQIRKT RVFRQYYPVD VPVLRKVTVV KPVHLERKVP VPRMVVKDVP
HHVVRTKKVD VPIDVPIKKI VEKKVVRYVE NKIFRPRPVV QEKVRVEHVP QPFPVDQVVV
KKNPRPRLIV EKKPVPVIRH IHTHKKQAVA VPRVKTVAEV VPNVVHQKVT YPVGKGGGSV
QIPGGPLPVP EHYKYKGYDK
