ID   MQNA_CAMJJ              Reviewed;         223 AA.
AC   A1W0R9;
DT   22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Chorismate dehydratase {ECO:0000255|HAMAP-Rule:MF_00995};
DE            EC=4.2.1.151 {ECO:0000255|HAMAP-Rule:MF_00995};
DE   AltName: Full=Menaquinone biosynthetic enzyme MqnA {ECO:0000255|HAMAP-Rule:MF_00995};
GN   Name=mqnA {ECO:0000255|HAMAP-Rule:MF_00995}; Synonyms=mqnA2;
GN   OrderedLocusNames=CJJ81176_1302;
OS   Campylobacter jejuni subsp. jejuni serotype O:23/36 (strain 81-176).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Campylobacteraceae; Campylobacter.
OX   NCBI_TaxID=354242;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=81-176;
RA   Fouts D.E., Nelson K.E., Sebastian Y.;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DISRUPTION PHENOTYPE, ROLE IN MENAQUINONE BIOSYNTHESIS, AND PATHWAY.
RC   STRAIN=NCTC 11168;
RX   PubMed=21489995; DOI=10.1074/jbc.m111.229781;
RA   Li X., Apel D., Gaynor E.C., Tanner M.E.;
RT   "5'-methylthioadenosine nucleosidase is implicated in playing a key role in
RT   a modified futalosine pathway for menaquinone biosynthesis in Campylobacter
RT   jejuni.";
RL   J. Biol. Chem. 286:19392-19398(2011).
CC   -!- FUNCTION: Catalyzes the dehydration of chorismate into 3-[(1-
CC       carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone
CC       (MK, vitamin K2). {ECO:0000255|HAMAP-Rule:MF_00995}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O;
CC         Xref=Rhea:RHEA:40051, ChEBI:CHEBI:15377, ChEBI:CHEBI:29748,
CC         ChEBI:CHEBI:76981; EC=4.2.1.151; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00995};
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC       {ECO:0000255|HAMAP-Rule:MF_00995, ECO:0000269|PubMed:21489995}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene do not grow on standard
CC       rich medium; however, growth of these mutants is readily rescued by the
CC       addition of aminodeoxyfutalosine, but not futalosine.
CC       {ECO:0000269|PubMed:21489995}.
CC   -!- SIMILARITY: Belongs to the MqnA/MqnD family. MqnA subfamily.
CC       {ECO:0000255|HAMAP-Rule:MF_00995}.
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DR   EMBL; CP000538; EAQ72714.1; -; Genomic_DNA.
DR   RefSeq; WP_002854065.1; NC_008787.1.
DR   AlphaFoldDB; A1W0R9; -.
DR   SMR; A1W0R9; -.
DR   STRING; 354242.CJJ81176_1302; -.
DR   EnsemblBacteria; EAQ72714; EAQ72714; CJJ81176_1302.
DR   KEGG; cjj:CJJ81176_1302; -.
DR   eggNOG; COG1427; Bacteria.
DR   HOGENOM; CLU_059898_1_0_7; -.
DR   OMA; VFIKSYP; -.
DR   UniPathway; UPA00079; -.
DR   Proteomes; UP000000646; Chromosome.
DR   GO; GO:0016836; F:hydro-lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00995; MqnA; 1.
DR   InterPro; IPR003773; Menaquinone_biosynth.
DR   InterPro; IPR030868; MqnA.
DR   PANTHER; PTHR37690; PTHR37690; 1.
DR   Pfam; PF02621; VitK2_biosynth; 1.
PE   3: Inferred from homology;
KW   Lyase; Menaquinone biosynthesis.
FT   CHAIN           1..223
FT                   /note="Chorismate dehydratase"
FT                   /id="PRO_0000425125"
SQ   SEQUENCE   223 AA;  25707 MW;  FE1EE1772CB05D39 CRC64;
     MIFGKIDYIN LLPLHIYLKK YPLPNGYKAN MEYKKGVPSK LNKDLFYRRI DAAIISSIES
     ARKKYKNLDL GICANKRVLS VLVEKNTSNA KDPSSATSNA LAKVLKQDGK VIIGDKALKL
     YLKDPSKYID LCAKWHEKTG LPFVFARFSC VQKKALYKQI LKKFPKTKIK IPYYILQNYA
     KTRDLDIKDV RYYLDEVIYH KISTKEKTAL KRFVKACKAL NLA