ID   MQO1_PSEAE              Reviewed;         523 AA.
AC   Q9HYF4;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Probable malate:quinone oxidoreductase 1 {ECO:0000255|HAMAP-Rule:MF_00212};
DE            EC=1.1.5.4 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=MQO 1 {ECO:0000255|HAMAP-Rule:MF_00212};
DE   AltName: Full=Malate dehydrogenase [quinone] 1 {ECO:0000255|HAMAP-Rule:MF_00212};
GN   Name=mqo1 {ECO:0000255|HAMAP-Rule:MF_00212}; Synonyms=mqoA;
GN   OrderedLocusNames=PA3452;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-malate + a quinone = a quinol + oxaloacetate;
CC         Xref=Rhea:RHEA:46012, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.4;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00212};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle;
CC       oxaloacetate from (S)-malate (quinone route): step 1/1.
CC       {ECO:0000255|HAMAP-Rule:MF_00212}.
CC   -!- SIMILARITY: Belongs to the MQO family. {ECO:0000255|HAMAP-
CC       Rule:MF_00212}.
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DR   EMBL; AE004091; AAG06840.1; -; Genomic_DNA.
DR   PIR; C83213; C83213.
DR   RefSeq; NP_252142.1; NC_002516.2.
DR   RefSeq; WP_003102300.1; NZ_QZGE01000037.1.
DR   AlphaFoldDB; Q9HYF4; -.
DR   STRING; 287.DR97_4469; -.
DR   PaxDb; Q9HYF4; -.
DR   PRIDE; Q9HYF4; -.
DR   EnsemblBacteria; AAG06840; AAG06840; PA3452.
DR   GeneID; 879029; -.
DR   KEGG; pae:PA3452; -.
DR   PATRIC; fig|208964.12.peg.3614; -.
DR   PseudoCAP; PA3452; -.
DR   HOGENOM; CLU_028151_0_0_6; -.
DR   InParanoid; Q9HYF4; -.
DR   OMA; PHLDTRW; -.
DR   PhylomeDB; Q9HYF4; -.
DR   BioCyc; PAER208964:G1FZ6-3520-MON; -.
DR   UniPathway; UPA00223; UER01008.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0052589; F:malate dehydrogenase (menaquinone) activity; IEA:UniProtKB-EC.
DR   GO; GO:0008924; F:malate dehydrogenase (quinone) activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00212; MQO; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006231; MQO.
DR   Pfam; PF06039; Mqo; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01320; mal_quin_oxido; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome;
KW   Tricarboxylic acid cycle.
FT   CHAIN           1..523
FT                   /note="Probable malate:quinone oxidoreductase 1"
FT                   /id="PRO_0000128729"
SQ   SEQUENCE   523 AA;  57210 MW;  03E90117F88890B3 CRC64;
     MKKILLMLLC VSVLGCSKNS VESEKPVDVL LIGGGIMSAT LGTYLNELEP GWTIEMVERL
     DKVAEESSNG WNNAGTGHSA FCELNYTSEA ADGSMDISKA VAINENFEIS KQFWAYQVDR
     KVLNDPKSFI NNVPHMSFVW GDDNVAFLKK RHAALQHSSL FRGMEYSEDP EQIKQWVPLV
     MEGREPGQKI AATRMSIGTD VNFGEITRQL VGSLSAKDTF KLRLQHEVRD LKRNDDNTWT
     VTMADLANGD KETSVKARFV FIGAGGGALK LLQMSGIPEA EGYAGFPVGG SFLATTNPDV
     VKRHLAKVYG KASVGSPPMS VPHLDTRMID GKPVLLFGPF ATFSTKFLKN GSLWDLPGSV
     TSGNIGPMFN AGIDNFDLSQ YLIGQLMLSQ DDRMASLREY FPEARDEDWK LVQAGQRVQI
     IKKDAEKGGV LQFGTEVVTA ADGSVAALLG ASPGASTAAP IMLSVLEKAF KDKVATPEWQ
     ARLKEIVPSY GRKLNNDIEL TNSTRAWSSE RLQLIHVPVQ PEA